Understanding neuromusculoskeletal interactions underlying biomechanics and control of the human hand

灵巧的手功能是人类身份的一个决定性特征。在几乎所有的日常生活活动中，从早上穿衣服到晚上准备晚餐，手都是至关重要的。完全对生的拇指对手部功能尤其重要，它可以通过抓握或捏捏来与物体和工具进行交互。虽然手的多功能性是现代人类智慧的中心主题，但其复杂的解剖结构挑战了我们对机械功能和神经肌肉控制的理解。手工密集型任务的成功执行最终依赖于神经生理（如感觉和运动神经）和生物力学装置（如肌肉和肌腱）的无缝相互作用。然而，研究这些系统如何相互作用以保持手的功能是非常必要的，特别是在需要在线控制姿势和握力的复杂职业任务中。我的研究将使用一种创新的，跨学科的方法来研究手部生物力学和神经肌肉控制。本研究将分为三个主题：(1)确定机械相互作用；(2)通过实验操纵感觉运动通路，阐明生物力学与神经生理学之间的联系；(3)开发能够表示手部神经肌肉骨骼耦合的计算机模型。

Dexterous hand function is a defining feature of the human identity. The hand is vitally important in nearly all activities of daily living, from getting dressed in the morning to preparing dinner in the evening. The fully opposable thumb is especially crucial to hand function, enabling interaction with objects and tools via gripping or pinching. While the hand’s versatility is a central theme in modern human ingenuity, its complex anatomy challenges our understanding of mechanical function and neuromuscular control. Successful performance of a hand-intensive task ultimately relies on the seamless interaction of neurophysiological (e.g. sensory and motor nerves) and biomechanical apparatus (e.g. muscles and tendons). However, there is an immense need to investigate how these systems interact with each other to preserve hand function, especially during complex occupational tasks that require online control of postures and grip forces. My research will use an innovative, inter-disciplinary approach to investigate hand biomechanics and neuromuscular control. This research will be organized in three themes: (1) Determining mechanical interactions; (2) Elucidating links between biomechanics and neurophysiology by experimentally manipulating sensorimotor pathways; (3) Developing a computer model capable of representing neuromusculoskeletal coupling within the hand.