权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

NeuronS_MATTR Network: Neuronal & Systems Mechanisms of Affective Touch & Therapeutic Tissue Manipulation Research Network

NeuronS_MATTR 网络：神经元

基本信息

批准号：
10612050
负责人：
Gregory John Gerling
金额：
$ 63.94万
依托单位：
UNIVERSITY OF CALIFORNIA BERKELEY
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-20 至 2027-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10612050
关键词：
Adult Affect Affective American Animal Model Area Attenuated Basic Science Biological Cells Chronic Clinical Collaborations Computer Models Development Discipline Engineering Epithelial Cells Ethnic Origin Fibroblasts Fostering Gender Geographic Locations Goals Health Human Immune Immune system Individual Industry Inflammation Integumentary system Interdisciplinary Study Intervention Intractable Pain Knowledge Mammals Manipulative Therapies Manuals Massage Measures Mechanical Stimulation Mechanics Mediating Methodology Mission Molecular Moods Mus Musculoskeletal System Nervous System Nervous System Physiology Neural Pathways Neurobiology Neurons Neurosciences Pain Pain management Pathway interactions Patient Outcomes Assessments Patients Pharmacological Treatment Physical therapy Physiological Physiology Pilot Projects Population Publications Relaxation Research Research Personnel Research Priority Resources Schools Scientist Signal Transduction Stress System Techniques Technology Therapeutic Therapeutic Effect Therapeutic Touch Tissues Touch sensation anxiety reduction body system career cell type cytokine equity, diversity, and inclusion healing human subject innovation innovative technologies intersectionality mechanical stimulus multidisciplinary neural neuromechanism neuromusculoskeletal opioid epidemic pain relief pharmacologic program dissemination programs psychosocial repaired response social socioeconomics soft tissue spatiotemporal symposium tool

项目摘要

ABSTRACT / PROJECT SUMMARY The goal of this proposal is to establish a high-priority research network to identify mechanisms through which soft tissue manipulation (STM), such as massage, exerts biological effects on the nervous system, non-neural cells and tissues. Neuromusculoskeletal pain afflicts up to half of the adult U.S. population and is the most commonly cited health reason for receiving massage. Soft tissue manipulation has been shown to promote relaxation, reduce anxiety, attenuate pain, mitigate inflammation, and promote functional change. STM also offers non-addictive alternatives to pharmacological interventions for short-term pain relief. Although STM has been used widely since ancient times, the underlying mechanisms of STM’s beneficial effects are not well understood, and STM interventions are not optimized based on rigorous and compelling scientific evidence. Although mechanistic studies over the past decade have identified molecular, cellular and circuit mechanisms of discriminative touch sensation in mammals, how these neural pathways are engaged by STM is unknown. Moreover, the cells and circuits that mediate affective components of touch sensation have not been defined. To enable mechanistic research into therapeutic effects of STM, interdisciplinary research and new resources are needed. The field requires collaboration between manual therapists, neuroscientists, engineers, and cell biologists. Scientific conferences or other networking opportunities that bridge these disciplines do not currently exist. This application in response to RFA-AT-21-006 will create a cross-disciplinary research network of scientists and clinicians with the shared goal of developing technologies and collaborations to break barriers to progress. First, few quantifiable standards exist to rigorously measure either how therapists apply hands-on manipulations, or how these manipulations alter stress/strain fields in receiving tissues. Second, the field lacks technologies and computational models to quantify the spatiotemporal dynamics of STM techniques. Third, how non-neural signals and cell types, including cytokines, immune cells, fibroblasts, and epithelial cells, promote restorative repair versus fibrotic healing have not been defined. Our core investigative team consists of scientists and clinicians whose collective expertise spans physical therapy, neuroscience from molecules to circuits in the mouse and human nervous systems, engineering and tissue mechanics, and extraneural tissues including the immune, myofascial and integumentary systems. To advance mechanistic research on STM and mechanosensory signaling, the U24 network aims to 1) Organize a Conferences Program to promote inclusive networking and cross-disciplinary collaborations, draw diverse researchers and clinicians to the field, and foster mechanistic, multi-scale research on the neurobiology of mechanotherapy. 2) Implement a Pilot Project Program to generate new tools for quantifying force-based manipulations, testable hypotheses, and new mechanistic knowledge. 3) Rapidly and freely disseminate high-impact research to advance the field by sharing innovative concepts and technologies that define neural mechanisms of the beneficial effects of STM.

摘要/项目摘要这项提议的目标是建立一个高度优先的研究网络，以确定下列机制软组织手法(STM)，如按摩，对神经系统、非神经系统产生生物效应细胞和组织。神经肌肉骨骼疼痛困扰着多达一半的美国成年人，是最严重的经常提到的接受按摩的健康原因。软组织手法已被证明可以促进放松，减少焦虑，减轻疼痛，减轻炎症，促进功能改变。STM还为短期止痛提供药物干预的非成瘾性替代方案。尽管STM拥有 STM自古以来就被广泛使用，但其有益作用的潜在机制尚不清楚理解，而且STM干预措施没有基于严格和令人信服的科学证据进行优化。尽管过去十年的机制研究已经确定了分子、细胞和电路机制哺乳动物的辨别性触觉，这些神经通路是如何被STM参与的尚不清楚。此外，调节触觉情感成分的细胞和电路还没有被定义。使STM治疗效果的机械性研究、跨学科研究和新资源成为可能都是需要的。这一领域需要手动治疗师、神经学家、工程师和细胞之间的合作生物学家。连接这些学科的科学会议或其他网络机会目前还没有是存在的。该应用程序响应RFA-AT-21-006，将创建一个跨学科的研究网络科学家和临床医生的共同目标是开发技术和合作，以打破障碍进步。首先，几乎没有可量化的标准来严格衡量治疗师如何亲身实践手法，或这些手法如何改变接受组织中的应力/应变场。其次，该领域缺乏用于量化STM技术时空动力学的技术和计算模型。第三，如何非神经信号和细胞类型，包括细胞因子、免疫细胞、成纤维细胞和上皮细胞，促进恢复性修复与纤维性愈合之间的关系尚未明确。我们的核心调查团队由科学家组成和临床医生，他们的集体专业知识横跨物理治疗，神经科学，从分子到电路小鼠和人类神经系统、工程学和组织力学，以及包括免疫系统、肌筋膜系统和外膜系统。推进扫描隧道显微镜的机理研究机械感应信号，U24网络的目标是1)组织一个会议计划，以促进包容性网络和跨学科协作，将不同的研究人员和临床医生吸引到该领域，并促进机械化、多尺度的机械疗法神经生物学研究。2)实施试点项目计划生成用于量化基于力的操作、可测试的假设和新机制的新工具知识。3)迅速和自由地传播高影响力的研究，通过分享创新成果来推动该领域的发展定义STM有益效果的神经机制的概念和技术。