Hippocampal cortical interactions and the extraction of knowledge from episodic memory

我的研究项目主要集中在记忆的神经计算基础和神经元群体之间的动态相互作用，这些相互作用导致了大脑创造其自适应模型的能力。在过去的35年里，我在理解中枢突触可塑性机制、空间信息处理、皮质-海马体相互作用和记忆巩固方面做出了重大贡献，并在系统神经科学研究方面取得了重大进展。在这项工作中，我培养了33名优秀的研究生和37名博士后，其中大部分人在各大大学从事研究工作。在接下来的5年里，我的总体计划（包括其他支持）将为至少4名本科生，10名研究生和7名博士后提供培训，因为我们将继续研究海马背投射到新皮层对神经编码和神经可塑性的影响。理解这种影响是理解为什么在海马体功能缺失的情况下，新皮层无法形成新的记忆或有效地从经验中提取一般知识的关键。这也是理解一种可能对信息和计算机技术产生深远影响的计算知识获取和表示模式的关键。

My research program focusses on the neuro-computational basis of memory and the dynamic interactions among neuronal populations that lead to the brain’s ability to create an adaptive model of its. Over the past 35 years, I have made major contributions to understanding central synaptic plasticity mechanisms, spatial information processing, cortico-hippocampal interactions and memory consolidation, and significantly advanced technologies for systems neuroscience investigation. In the course of this work I have provided outstanding training to 33 graduate students, and 37 postdocs, most of whom are pursuing research careers at major universities. Over the next 5 years, my overall programme (including other support) will provide training for at least 4 undergrads, 10 graduates and 7 postdocs, as we continue to study the impact of hippocampal back projections to the neocortex on neural coding and neural plasticity in that structure. Understanding this impact is key to understanding why, in the absence of a functional hippocampus, the neocortex is unable to form new memories or to extract general knowledge from experience efficiently. It is also key to understanding a mode of computational knowledge acquisition and representation that may have far reaching impacts on information and computer technology.