The roles of PAPP-A2 and IGF signaling in reproduction

生殖需要几个生理系统的协调和对不同挑战的适当反应。在胎盘哺乳动物中，胎盘在妊娠期间为胎儿提供营养和氧气是至关重要的，之后后代的营养依赖于哺乳，这对母体骨骼有深刻而短暂的影响。胰岛素样生长因子(IGF)是胎盘发育和功能所必需的，可能与哺乳期母体骨骼的变化有关。妊娠相关血浆蛋白-A2(PAPP-A2)是一种知之甚少的蛋白质，可能在生殖过程中调节IGF水平。我的研究目的是了解胎盘如何应对母体和/或发育挑战以实现成功的结局，母体骨骼如何适应怀孕和哺乳并在断奶期间恢复，以及这些胎盘和骨骼调整如何影响后代和母亲未来的健康。在未来五年内，拟议的研究将调查：

Reproduction requires the coordination of several physiological systems and appropriate responses to diverse challenges. In placental mammals, the placenta is crucial for supplying the fetus with nutrients and oxygen during gestation, after which offspring nutrition depends on lactation, which has profound but transient effects on the maternal skeleton. Insulin-like growth factor (IGF) is required for the development and function of the placenta, and is likely involved in the changes in the maternal skeleton that take place during lactation. Pregnancy-associated plasma protein-A2 (PAPP-A2) is a poorly understood protein that may be important in regulating IGF levels during reproduction. The objectives of my research are to understand how the placenta responds to maternal and/or developmental challenges to achieve a successful outcome, how the maternal skeleton adjusts to pregnancy and lactation and recovers during weaning, and how these placental and skeletal adjustments affect the future health of the offspring and mother. Over the next five years, the proposed research will investigate: