Sensorimotor control of vocal production.

在一生中，听到自己说话时的声音，也被称为听觉反馈，是至关重要的。在语言发育过程中，部分或全部耳聋会严重影响儿童的发音质量，甚至完全阻碍语言的正常发展。此外，越来越多的证据表明，口吃、帕金森氏症、自闭症谱系障碍甚至精神分裂症患者处理听觉反馈的方式与其他人不同。考虑到听觉反馈对流利言语的重要性，以及真正理解视听整合障碍的含义，我们有必要清楚地了解听觉反馈如何调节言语运动行为。这项研究计划的目标是促进我们对大脑如何使用听觉反馈来控制语言运动的理解。具体来说，我们将1)

Throughout life, hearing your own voice as you speak, also known as auditory feedback, is critically important. During speech development, partial or total deafness can severely affect the quality of a child's articulations or even prevent the normal development of speech all together. Moreover, there is growing evidence that people who stutter, have Parkinson’s disease, autism spectrum disorders, and even schizophrenia process their auditory feedback differently than other individuals. Given the importance of auditory feedback for fluent speech, and to truly understand the implications of disordered audio-vocal integration, it is imperative that we have a clear understanding of how speech motor acts are modulated by auditory feedback. The goal of this proposed research program is to advance our understanding of how the brain uses auditory feedback for speech motor control. Specifically, we will 1)