Investigation of Metal-Organic Hybrids as Photosensitizers for Bioinorganic Applications

我在NSERC的最后一段DG时期探索了配合物作为DNA光切割剂，这些化合物作为光动力治疗（PDT）的光敏剂。这种治疗癌症的策略，即光敏剂的光激活产生细胞毒性单线态氧，由于对氧气的依赖而受到损害，在最具侵袭性的肿瘤中，氧气通常是有限的。我的团队利用其多学科专业知识，在配位化学中利用新的光物理原理，通过某些光敏剂结构引起不依赖氧的DNA光损伤。我们首先证明了高活性的三联体配体(

My last NSERC DG period explored coordination complexes as DNA photocleaving agents, compounds that have utility as photosensitizers for photodynamic therapy (PDT). This strategy for treating cancer, whereby light activation of a photosensitizer produces cytotoxic singlet oxygen, is compromised by its reliance on oxygen, which is often limited in the most aggressive tumours.  My group used its multidisciplinary expertise to exploit novel photophysical principles in coordination chemistry to elicit oxygen-independent DNA photodamage by certain photosensitizer constructs. We were the first to show that highly reactive triplet intraligand (