New Methods for Green Organic Synthesis

我们的建议侧重于开发铁和铋衍生的Lewis酸作为绿色催化剂。它们在合成化学中的应用需要进一步开发，因为与其他金属相比，它们是环境友好、相对无毒和经济的。我们的研究目标是开发新的合成方法，重点是直接制备药物分子的催化和对映选择性程序。在现代有机合成中，催化不对称过程对于合成富含对映体的化合物是必不可少的，与需要化学计量比的手性试剂的方法相比，它提供了更经济和环境友好的过程。我们的结果将导致新的工具来制备生物感兴趣的分子。这些研究将有助于开发使用环境友好和更经济的Lewis酸催化剂的绿色合成新方法。

Our proposal focuses on the development of iron and bismuth-derived Lewis acids as green catalysts. Their use in synthetic chemistry needs to be further developed because they are environmentally benign, relatively nontoxic and economic in comparison to other metals. The objective of our research is the development of new synthetic methods, with emphasis on catalytic and enantioselective procedures for the straightforward preparation of molecules of pharmaceutical interest. Catalytic asymmetric processes are indispensable for producing enantiomerically enriched compounds in modern organic synthesis, providing more economical and environmentally benign processes than methods requiring stoichiometric amounts of chiral reagents. Our results will lead to new tools for the preparation of molecules of biological interest. These studies will contribute to the development of new green synthetic methods using environmentally friendly and more economical Lewis acid catalysts.