Improving Efficiency in Organic Synthesis via Catalytic Reactions

有机合成的未来需要化学家们发现和开发新的反应和新的策略，以便解决紧迫的问题，即识别新的药剂、农用化学品和材料，同时减少产生的废物，并找到更有效的方法来制造最终产品。我们的研究解决了与提高有机合成效率相关的两个重大而持久的问题。我们寻求确定新的化学变化，这些变化有可能通过扩大社区可用的化学反应体系来改变我们制作感兴趣的产品的方式。理想情况下，新反应是反应伙伴的简单组合，以便最大限度地减少浪费。如果要被广泛采用，反应需要是可扩展的、简单和实用的。此外，我们正在确定新的战略，以简化在实验室进行合成的方式，以减少与合成序列中的操作相关的浪费。

The future of organic synthesis requires chemists to discover and develop new reactions and new strategies in order to address the pressing issues of identifying new medicinal agents, agrochemicals and materials while at the same time producing less waste and finding more efficient ways of making the end products. Our research addresses two significant and enduring problems associated with improving efficiency in organic synthesis. We seek to identify new chemical transformations that have the potential to change how we make a product of interest by expanding the repertoire of chemical reactions that are available to the community. Ideally new reactions are simple combinations of the reacting partners so as to minimize waste. Reactions need to be scalable, simple and practical if they are to be widely adopted. In addition we are identifying new strategies to streamline the ways synthesis is conducted in the laboratory so as to reduce the waste associated with operations in a synthetic sequence.