Nanoprobes to reveal signature biomarkers

细胞对不同损伤刺激的适应能力是推动进化的主要力量之一。细胞适应的潜在机制还不完全清楚。溶酶体是一种动态细胞器，长期以来一直被认为是垃圾焚烧炉，最近被认为是细胞适应的重要角色。溶酶体的功能在转录和转录后水平上受到调节，这些功能对细胞外和细胞内的提示做出反应。转录因子EB(TFEB)是溶酶体功能的主要调节者。它的状态取决于上游的激酶活性。

The ability of cells to adapt to different injurious stimuli is one of the major forces driving evolution. The mechanisms underlying cell adaptation are not fully understood. Lysosomes, dynamic cellular organelles which were considered for a long time only “garbage incinerators” have been recently proposed as essential players in cellular adaptation. Lysosomal functions are regulated at transcriptional and posttranscriptional levels and these functions respond to extracellular and intracellular cues. Transcription factor EB (TFEB) is a master regulator of lysosomal functions. Its status depends on upstream kinase activities.