Development and validation of novel bioactive biodegradable metals for high performance biomaterials

生物医学设备行业的梦想是为患者和临床医生提供新一代植入物，这些植入物可以执行其功能，然后溶解在宿主体内，消除当前永久性植入物的有害影响。生物可降解金属具有强度、延展性和可降解性，被认为是制造理想植入物的理想材料。关于生物可降解金属的已发表论文从2005年的不到50篇大幅增加到10年来的2 000多篇。这些金属一直吸引着学术界和工业界的研究人员，因为它们可能会彻底改变医疗产品。未来的趋势是增加生物活性和探索新的临床应用，需要暂时存在的承重植入物。其最新进展之一是将其多孔结构引入骨支架。我是第一个介绍多孔可生物降解金属支架的人，我的工作是研究多孔铁-聚乳酸-

The dream of biomedical device industries is to provide patients and clinicians with a new generation of implants that can perform its function then dissolve in the host body, eliminating the harmful effects of current permanent implants. Biodegradable metals, having the combination of strength, ductility and degradability, have been viewed as the ideal materials for making those dreamed implants. Published works on biodegradable metals have been significantly increasing from less than 50 papers in 2005 to more than 2,000 over 10 years. These metals have been attracting researchers in academia and industries alike as they can potentially revolutionize the medical products. The future trend goes toward adding bioactivities and exploring new clinical applications that require a temporary presence of load bearing implants. One of the latest development is the introduction of its porous structure for bone scaffolds. I am among the first to introduce porous biodegradable metal scaffolds with the works on new composites of porous iron-poly(lactic-