Multibody dynamic modeling of the upper limb for the quantification of muscle force co-contraction and synergy strategies during motion

这个生物医学工程研究项目的目标是量化健康成年人上肢运动过程中的个体肌力。这也将能够解释肌肉协同收缩策略的时间演变，即关节两侧肌肉的相反动作，以及协同作用，即关节同一侧肌肉的联合动作，用于基础知识和未来在体育、机器人、康复、骨科、人体工效学和/或预防方面的创新应用。该计划包括3个具体目标：1.开发生物逼真和个性化的上肢动态模型，能够量化运动过程中的肌力。2.尽可能使用神经运动阻滞剂进行验证，即局部麻醉选定的肌肉。3.用它来理解在屈/伸、旋前/旋后和指点任务中的肌肉过度驱动策略。本研究项目的新颖性是双重的：1.这一目标将通过一种独特的科学方法实现，该方法基于一种生物逼真和个性化的动态方法来评估人体运动中的肌肉力量。这一目的是为了提高对运动过程中人体肌肉过度驱动的理解，这在文献中是完全创新的，并且在临床和工业领域对个性化肌肉力量量化的当前需求非常感兴趣。主要的应用领域将是康复和骨科领域，用于评估和跟踪肌肉骨骼病理和辅助装置的设计，以及运动领域，用于分析和提高运动成绩。本科生和研究生的培训是这一多学科研究计划的基本组成部分，这将使他们在应用力学(生物力学建模、多体动力学)和实验(实验方案设计、误差分析、重复性和灵敏度分析)方面发展强大的技能。最后，这项研究计划还将有助于开展国际合作。

The goal of this biomedical engineering research program is to quantify individual muscle forces during upper limb motion in healthy adults. This will also enable to explain the temporal evolution of muscle strategies of co-contraction, i.e. opposite actions of muscles on each side of a joint, and synergy, i.e. joint actions of muscles on the same side of a joint, for fundamental knowledge and future innovative applications in sports, robotics, rehabilitation, orthopedics, ergonomics and/or prevention. The program includes 3 specific objectives: 1. Develop a biofidelic and personalized dynamic model of the upper limb, enabling to quantify muscle forces during motion. 2. Validate it as far as possible using nerve motor blocs, i.e. locally anesthetizing selected muscles. 3. Use it to understand the muscle overactuation strategies during flexion/extension, pronation/supination, and pointing task.The novelty of this research program is double:1. The goal will be achieved through a unique scientific approach based on the development of a biofidelic and personalized dynamic method assessing the muscle forces in the human body in motion.2. This objective of improving the understanding of muscle overactuation in the human body during motion is completely innovant in literature and of great interest concerning current demands for personalized muscle force quantification in the clinical and industrial domains. The main fields of applications will be rehabilitation and orthopedic domain for the evaluation and follow-up of musculo-skeletal pathologies and the design of assistive device, and the sport domain for the analysis and improvement of athletic performance. The trainingship of undergraduate and graduate students is a fundamental part of this multi-disciplinary research program, which will allow them to develop strong skills in applied mechanics (biomechanical modeling, multibody dynamics) and experimentation (design of experimental protocol, analyses of error, reproducibility and sensitivity). Finally, this research program will also enable to develop international collaborations.