The effects of Selko Elarom Poultry on intestinal inflammation in broiler chickens

球虫病是肉鸡的一种寄生虫病。由球虫引起的病变是坏死性肠炎的一个预处置因素，坏死性肠炎是一种与全世界家禽生产者每年> 60亿美元的经济损失相关的疾病。在常规生产中，球虫病和坏死性肠炎是通过抗球虫和抗生素管理来预防和管理的。然而，在无抗生素饲养（RWA）计划中，抗生素的使用是禁止的。在RWA生产中，球虫病可以通过接种疫苗来预防，但并非没有风险。疫苗中含有活的寄生虫，它们会在肠道内复制多次，在此过程中会损害肠道器官。肠道损伤导致炎症和肠道完整性标志物的减少，这些标志物与接种疫苗后体重增加的减少有关。促进肠道正常功能的饲料添加剂可能有助于减轻活疫苗引起的肠道损伤。由Trouw Nutrition生产的Selko Elarom Poultry（ElrM）是酚类化合物、短链和中链脂肪酸以及有机酸的协同混合物。Trouw Nutrition之前完成的内部研究表明，ElrM可提高饲料转化率，这是一个支持在RWA应用中使用Elarom的生长指数。然而，这些影响的机制基础尚未阐明。这是一个需要解决的重要问题，因为它将提供进一步的经验证据来支持使用Selko Elarom Poultry，并减少球虫病和疫苗接种的经济影响。因此，该公司希望调查的问题，以及拟议工作的目标是检查Elarom对肉鸡生殖道炎症指数和肠道完整性的影响。Trouw Nutrition没有专业知识来回答这个问题，随后与该领域的专家Wright博士合作。这项工作将为深入了解ElrM的作用机制提供重要的见解，并将是扩大ElrM在其他物种中使用的重要一步。

Coccidiosis is a parasitic condition of broiler chickens. The lesions casued by coccidia are a pre-disposingfactor for necrotic enteritis, an ailment that is associated with world wide economic losses to poultry producersof > $6 billion annually. In conventional production, coccidiosis and necrotic enteritis are prevented andmanaged through anti-coccidial and antibiotic administration. However the use of antibiotics are prohibitedduring the bird's life in raised without antibiotic (RWA) feeding programs. In RWA production, coccidiosis canbe prevented through vaccination, yet not without risk. Vaccines contain live parasites, which replicate anumber of times through the intestines, damaging the organ in the process. Damage to the intestine results ininflammation and reductions in markers of gut integrity that have been linked to decreases in weight gainfollowing vaccination. Feed additives that promote proper intestinal functioning may prove beneficial inmitigating the intestinal damage induced by live vaccines. Selko Elarom Poultry (ElrM), produced by TrouwNutrition, is a synergistic blend of phenolic compounds, short and medium chain fatty acids, and organic acids.Previous in-house studies completed by Trouw Nutrition have demonstrated that ElrM improves feedconversion ratio, an index of growth supporting the use of Elarom in RWA applications. However, themechanistic underpinnings of these effects have not been elucidated. This is an important question to address,as it will provide further empirical evidence to support the use of Selko Elarom Poultry and reduce theeconomic impact of Coccidiosis and vaccination against it. Therefore the problem the company would like toinvestigate, and the objective of the proposed work is to examine the effects of Elarom on indices of intestinalinflammation and gut integrity in broiler chickens. Trouw Nutrition does not have the expertise to answer thisquestion and has subsequently partnered with Dr. Wright, an expert in this area. The work in this proposal willprovide important insight into the mechanisms of action of ElrM and will be an important step in expandingthe use of ElrM in other species.