Portable BioMEMS sensor system for impaired driving detection

与大麻使用相关的挥发性有机化合物（VOC）和非VOC在吸入后的前几个小时内存在于呼出气中。传统上，这些生物标志物的存在使用常规的气相色谱-质谱（GC-MS）系统检测。GC-MS还可以高精度地测量单位体积中这些生物标志物的浓度水平。然而，这些系统通常体积庞大且高度专业化。因此，该项目研究了一种微型传感器的开发，以检测呼出气体中与大麻使用相关的目标生物标志物。先进的微机械传感器系统由于其集成到便携式电子设备、设备小型化、低功耗、低成本和高制造产量的潜力而成为实用的、非侵入性的和灵敏的诊断工具。他们利用先进的微加工技术，将微加工和集成的显著优势转移到医学和环境监测领域。在这项工作中，微机械传感器原型将被设计和制造，可以提供所需的生物标志物在生理相关水平的实时检测。该技术提供了集成潜力，因此可以解决公司当前的挑战和集成小型化系统的需求。**

Volatile Organic Compounds (VOC) and non-VOC associated with the Cannabis use are present in the exhaled breath within the first few hours of inhalation. Traditionally, the presence of these biomarkers is detected using the conventional Gas Chromatography-Mass Spectrometry (GC-MS) system. GC-MS can also measure concentration level of these biomarkers in a unit volume with high accuracy. However, these systems are often bulky and highly specialized. Therefore, this project investigates the development of a miniaturized sensor to detect the targeted biomarkers associated with Cannabis use in the exhaled breath. Advanced micromachined sensor systems are emerging as practical, non-invasive and sensitive diagnostic tools due to their potential for integration into portable electronics, device miniaturization, low power consumption, low cost and high fabrication yield. They leverage advanced microfabrication techniques that transfer significant benefits of micromachining and integration to the fields of medicine and environmental monitoring. In this work, a micromachined sensor prototype will be designed and fabricated that can provide a real-time detection of desired biomarkers at the physiologically relevant level. This technology provides potentials for integration and therefore, can address the company's current challenges and needs of incorporating a miniaturized system.**