Bio-MicroElectroMechanical Systems (BioMEMS) Resource Center

生物微机电系统 (BioMEMS) 资源中心

• 批准号: 8308406
• 负责人: Mehmet Toner
• 金额: $ 117.86万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2014-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8308406
• 关键词: Address; Area; Basic Science; Behavior; Biochemistry; Biological; Biological Sciences; Biology; Biomedical Engineering; Biosensor; Biotechnology; Blood; Cell Separation; Cells; Cellular biology; Chemistry; Clinical; Clinical Investigator; Collaborations; Communication; Communities; Complement; Complex; Devices; Diagnostic; Disease; Educational workshop; Electronics; Engineering; Event; Faculty; Fee-for-Service Plans; Funding; Gene Chips; Gene Expression; Generations; Genes; Goals; Housing; Human; Industry; Injury; Internet; Laboratories; Licensing; Life; Longevity; Maintenance; Medical; Medicine; Methods; Microfabrication; Microfluidics; Mission; Molecular Biology; Monitor; Motion; Nervous System Trauma; Neurodegenerative Disorders; Organism; Outsourcing; Pharmacologic Substance; Preclinical Drug Evaluation; Publications; Reporter; Research Personnel; Resources; Sampling; Science; Scientist; Screening procedure; Services; Slice; Sorting - Cell Movement; Stimulus; Structure; Surface; System; Systems Biology; Techniques; Technology; Technology Transfer; Therapeutic; Time; Tissue Engineering; Tissue Microarray; Tissues; Training; Training Activity; United States National Institutes of Health; Visit; Work; animal tissue; base; biological research; biological systems; biomedical scientist; commercialization; drug testing; experience; high throughput technology; implantable device; meetings; micro-total analysis system; microchip; microsystems; new technology; novel; particle; patient monitoring device; point-of-care diagnostics; prognostic; programs; promoter; research and development; response; sensor; symposium; systems research; technological innovation; tool

DESCRIPTION (provided by applicant): Microfabrication techniques or microelectromechanical systems (MEMS) that have revolutionized the electronics industry are now poised to revolutionize the pharmaceutical & biotechnology industries, & basic biomedical sciences. The two leading applications of microfabrication in biology include "genes-on-a-chip" to monitor the expression level of potentially all genes in humans & organisms simultaneously, & "lab-on-a-chip" type devices to perform high-throughput biochemistry in very small volumes. Equally exciting is recent advances in the understanding of cellular behavior in microenvironments have started to pave the way towards living micro-devices. The emerging integration of living systems & MEMS are expected to become key technologies in the 21st century of medicine with a broad range of applications varying from diagnostic, therapeutics, cell-based high-throughput drug screening tools, & basic & applied cell biology tools. The mission for the proposed NIH BioMEMS Resource Center is to bridge the gap between MEMS engineering & biomedical community to provide new technologies at the interface of MEMS & living biological systems to biomedical investigators & clinicians. In order to make the tools of BioMEMS available to the biomedical community, we focused our efforts on 2 core technological research & development projects. In Core Project 1, we will use inertial microfluidic technology for high-throughput & precise microscale control of cell & particle motion for sorting & analysis of disease specific "rare" cells in blood. In Core Project 2, we will develop broad utility "living cell array" platforms to study the dynamics of cellular & tissue response to a multitude of stimuli. Also, there are 23 collaborative projects that both utilize & help advance the core technologies. The BMRC also provides services to NIH investigators to use the tools of microsystems technology in biology & medicine. The Core, Collaborative, & Service activities are complemented with a rich portfolio of training & dissemination activities. Our collaborators & service users are extremely well-funded NIH investigators. The training activities include ad-hoc training, laboratory courses, & workshops. The dissemination activities are very broad encompassing publications, presentations, web presence, symposia & meetings, visiting faculty program, & technology transfer. We have also been very successful in disseminating our technologies through licensing & spin-off commercialization and the use of MEMS foundries for manufacturing of microchips. BMRC has been very successful in developing cutting-edge, enabling technologies at the Interface of MEMS & biology, & disseminating these technologies to the biomedical community via collaborations, service activities, & organized training & dissemination programs.

描述（由申请人提供）：彻底改变电子行业的微加工技术或微电机械系统（MEMS）现在有望彻底改变药品和生物技术行业，以及基本的生物医学科学。微生物化在生物学中的两个主要应用包括“芯片上的基因”，以同时监测人类和生物体中所有基因的表达水平，＆“实验室”类型的设备在非常小的体积中执行高通量生物化学。同样令人兴奋的是，了解微环境中细胞行为的最新进展已开始为生活微设备铺平道路。预计生命系统和MEM的新兴整合将成为21世纪医学的关键技术，其应用范围广泛，范围从诊断，治疗学，基于细胞的高通量药物筛查工具以及基本和应用细胞生物学工具各不相同。拟议的NIH BioMems资源中心的任务是弥合MEMS工程与生物医学界之间的差距，以向MEMS和Living Biological Systems的界面提供新技术，向生物医学研究人员和临床医生提供。为了使生物医学界可用的生物元素工具，我们将精力集中在2个核心技术研发项目上。在Core Project 1中，我们将使用惯性的微流体技术进行高通量和精确的细胞和粒子运动微观控制，以分类和分析血液中疾病特定的“稀有”细胞。在Core Project 2中，我们将开发广泛的效用“活细胞阵列”平台，以研究细胞和组织对多种刺激的反应的动力学。此外，还有23个协作项目既利用并帮助推进核心技术。 BMRC还向NIH研究人员提供服务，以在生物学和医学中使用微系统技术的工具。核心，协作和服务活动的补充是丰富的培训和传播活动组合。我们的合作者和服务用户是资金丰富的NIH调查员。培训活动包括临时培训，实验室课程和研讨会。传播活动是广泛的出版物，演示文稿，网络存在，研讨会和会议，访问教师计划和技术转移。通过许可和衍生商业化以及使用MEMS铸造厂制造微芯片，我们也非常成功地传播我们的技术。 BMRC在MEMS和生物学界面上开发了尖端的技术，并通过协作，服务活动以及有组织的培训与传播计划将这些技术传播到生物医学界。