Organic and Organometallic Chemistry

在过去的50年里，改善人类生活质量的药物活性制剂的发展对社会产生了巨大的影响。然而，由于临床候选药物的低成功率而增加的药物发现成本，促使人们对导致失败率的因素进行了认真的分析。*天然产物已被历史证明是药物发现的可靠先导化合物。然而，由于制备类似物进行结构-活性关系研究的相关问题，许多公司已经放弃了这种方法。该程序为快速构建药理学相关基序提供了新的工具，从而规避了类似系统之间翻译的问题。

The development of pharmacologically active agents that improve the quality of human *life has had an enormous societal impact over the last 50 years. Nevertheless, the *increasing cost of drug discovery due to the low success rate of clinical candidates *has prompted serious analysis of the factors that contribute to the the failure rate. *Natural products have historically proven reliable lead compounds for drug discovery. *Nevertheless, many companies have abandoned this approach due to the problems *associated with the preparation of analogs to conduct Structure Activity Relationship *Studies. This program provides new tools for the expeditious construction of *pharmacologically relevant motifs, which circumvent the problems with translation *between analogous systems.