Wavefront Sensorless and Computational Adaptive Optics for High Resolution Imaging

***本研究计划的目的是研究新的光学技术，以推进人类细胞分辨率眼科成像的最新技术。具体来说，基于波前无传感器自适应光学的眼科OCT成像技术将通过以下两个目标进行研究：***目标1：用于细胞分辨率视网膜成像的闭环波前无传感器自适应光学（WSAO） OCT:***WSAO OCT克服了传统波前传感器相关的问题，直接使用图像质量度量作为像差校正的优点函数。尽管在临床前和临床成像方面都取得了成功，但WSAO算法执行波前校正所需的时间有限，并且无法解释波前像差的时间变化。研究WSAO优化算法的新方法，减少优化时间，实现闭环像差校正。***目的2：平行波前无传感器自适应光学辅助大视场视网膜成像：***AO视网膜成像的视场有限，阻碍了其在临床环境中的广泛适应。它已经很好地建立了精细的空间分辨率提供的AO是有用的临床应用，然而，许多视网膜疾病的诊断依赖于视网膜的大视场成像。本文将研究一种新的平行WSAO像差校正方法，利用光学建模和并行WSAO优化相结合的方法确定不同的像差校正剖面。***我在生物光子学方面的研究项目的潜在影响是提高临床眼科诊断的成像技术，并创造新的工具来加速视力剥夺疾病实验疗法的临床前开发中的视觉研究。

***The purpose of this research proposal is to investigate novel optical techniques to advance the state of the art for cellular resolution ophthalmic imaging in humans. Specifically, wavefront sensorless adaptive optics based techniques will be investigated for ophthalmic OCT imaging through the following two objectives:***Objective 1: Closed-loop wavefront sensorless adaptive optics (WSAO) OCT for cellular resolution retinal imaging:***WSAO OCT overcomes the issues associated with conventional wavefront sensor, by directly using the image quality metric as a merit function for aberration correction. Despite its success in both preclinical and clinical imaging, WSAO is limited by time needed for the algorithm to perform the wavefront correction, and cannot account for temporal changes of the wavefront aberrations. Novel methods in WSAO optimization algorithm will be investigated to decrease the optimization time in order to perform closed-loop aberration correction.***Objective 2: Parallel wavefront sensorless adaptive optics assisted wide field of view retinal imaging:***AO retinal imaging's limited field of view is preventing its widespread adaptation in clinical environment. It has been well established that the exquisite spatial resolution afforded by AO is useful for clinical application, however, the diagnosis of many retinal diseases depend upon large field imaging of the retina. Novel parallel WSAO aberration correction will be investigated to apply different aberration correction profiles determined by the combination of optical modeling and simultaneous parallel WSAO optimization at different retinal eccentricities.***The potential impact of my research program in Biophotonics is to improve imaging technology for clinical ophthalmic diagnosis, and to create novel tools to accelerate vision research in the preclinical development of experimental therapies for vision robbing diseases.