Investigating mechanisms of action of silver oxynitrate: an unexplored silver compound with superior anti-biofilm activity.

几千年来，银一直被用作抗菌化合物。虽然20世纪40年代随着抗生素技术的出现，人们对银的兴趣减弱，但抗生素耐药性的发生导致了20世纪80年代银抗菌技术的复兴。从那时起，各种银化合物被用于局部抗菌应用，然而，关于银的有效性仍然没有达成共识，对银活性的机理研究仅限于单离子银。因此，银化合物的声誉受到了损害。该项目将首次对一系列银化合物的作用机理和抗药性进行研究，包括新型硝酸银。区分银的作用机制和抗菌素耐药性将有助于更好地了解疗效、建立共识结构、临床应用和新技术发展。这些发现将为临床医生和患者提供有效的选择，以管理抗生素耐药感染。从而减少加拿大卫生保健系统内的感染发生率和相关费用，目前估计为10亿加元。**

Silver has been used as an antimicrobial compound for thousands of years. Although interest in silver waned in the 1940s with the advent of antibiotic technologies, incidence of antibiotic resistance led to a resurgence in silver antimicrobial technologies in the 1980s. Since then, a variety of silver compounds have been used in topical antimicrobial applications, however, there is still no consensus on the efficacy of silver and mechanistic studies of silver activity are restrictive to singly ionic silver. As a consequence, silver compounds have a tarnished reputation. This project will be the first investigation into mechanisms of action and resistance for a range of silver compounds including the novel silver oxynitrate. Differentiating silver mechanisms of action and antimicrobial resistance will provide a greater understanding of efficacy, establishing structure for consensus, clinical use, and new technological developments. These findings will provide clinicians and patients with effective options for the management of antibiotic resistant infections. Resulting in lessened incidence of infection and associated costs, currently estimated at CAD$ 1 Billion, within the Canadian Health Care System.**