Pathways controlling actin remodeling during cell migration

这项提议的重点是在分子水平上理解细胞从一个地方迁移到另一个地方的机制。细胞的构造很像房屋；它们有一个内部坚硬的结构，比如构成房屋的木材，以及一个外部皮肤，类似于墙壁和屋顶。当细胞移动时，它们必须改变其外部和内部结构。科学家将这一过程描述为重塑。细胞生物学中的一个基本问题是了解重塑是如何控制的，以及它是如何与其他细胞过程(如细胞分裂)协调的。*这项提议有三个目标。首先，我们将确定Flna蛋白调节细胞迁移的途径。在第二部分中，我们将确定FHOD1和Vimentin这两种蛋白质之间的合作是如何控制细胞迁移的。在最终目标中，我们将确定PI4KIIIü蛋白如何控制细胞决定的方向。*这项工作希望了解细胞迁移的基本和基本过程。我们希望在科学的这一重要方面培训三个人。**

The focus of this proposal is on understanding, at the molecular level, the mechanisms by which cells migrate from one place to another. Cells are constructed much like houses; they have an internal rigid structure like the lumber that frames a home and an external skin akin to walls and a roof. When cells move, they must alter both their external and internal structure. Scientists describe this process as remodeling. A fundamental issue in cell biology is understanding how remodeling is controlled and how it is coordinated with other cellular processes such as cell divisions.******There are three goals of this proposal. In the first we will identify the pathway by which the FLNa protein regulates cell migration. In the second we will determine how co-operation between tow proteins, FHOD1 and Vimentin, control cell migration. In the final goal, we will determine how the protein PI4KIIIß controls in which direction cells decide to.******This works hopes to understand the basic and fundamental process of cell migration. We hope to train three people in this important aspect of science. **