Synthesis, Stereochemistry and Catalysis in Organosulfur Chemistry

每个发明家都需要一个知识背景数据库，他/她可以从中获取信息。这些信息与发明者的想法、想象力和技能相结合，创造出一种新的工艺或产品。如果信息数据库不能增长，发明者很快就会耗尽对发明难题至关重要的新的智力“原材料”。随着时间的推移，我们的社会将不再在经济、技术或文化上进步。在化学领域，发明通常包括新的药品、材料、食品以及家庭和农场的新产品。发明还可以包括新工艺****，以更经济和/或环境友好的方法生产现有产品。例如，化学数据库包含有关基本化学反应和化学成键理论的信息。通常，向数据库提供信息的研究人员无法预测何时或如何将他们的信息用于新的化学发明。*******提出的研究将扩大有关含硫化合物反应的知识。主要项目如下：****1。提出的化学将扩大我们的知识如何现有的键连接（立体化学）的分子在碳硫和碳氮键的形成过程中产生。预计将发现新的立体化学环境，为有机化学界提供额外的工具。****2。我们建议制备一些具有重要生物学意义的含硫化合物。其中两种化合物对了解稀有氨基酸的生物合成很重要。获得这些化合物将使生物化学家能够快速收集有关酶如何能够发挥作用的信息。另一个目标是香菇中含硫的成分，当香菇被煮熟时，它会赋予香菇味道。它的制备应能使人们对其转化为蘑菇风味的化学过程有更多的了解。****我们建议扩展我们已经建立的硫化学工具来创造新的配体。配体是一种在无数反应中促进金属催化的碳-碳键形成反应的化合物。然后我们就可以继续我们的配体制备，并执行那些碳-碳键形成反应，这样分子就可以构造出特殊的立体化学特征

Every inventor requires a background database of knowledge from which he/she draws information. That information is combined with the inventor's idea, imagination and skill to produce a new process or product. If the database of information was not able to grow, inventors would soon run out of new intellectual "raw materials" that are so essential to the inventive puzzle. In time, our society would no longer be economically, technologically or culturally progressive. In the chemical field, inventions often include new pharmaceuticals, materials, food products and new products for the home and farm. Inventions could also include new processes****to produce established products by substantially more economical and/or environmentally friendly methods. The chemistry database contains, for example, information regarding fundamental chemical reactions and theories of bonding in chemistry. Often, a researcher contributing to the database is unable to predict when or how their information will be utilized in new chemical inventions.*******The investigations proposed will expand the knowledge pertaining to reactions of sulfur containing compounds. The broad projects are as follows:****1. The proposed chemistry will expand our knowledge of how existing bonding attachments (stereochemistry) of molecules result during the formation of carbon-sulfur and carbon-nitrogen bonds. It is expected that new stereochemical environments will be found, providing additional tools to the organic chemistry community.****2. We are proposing the preparation of selected biologically important sulfur containing compounds. Two of these compounds are important to understanding the biosynthesis of rare amino acids. Access to these compounds will permit biochemists to quickly gather information about how enzyme are able to function. The other target is the sulfur containing component of shiitake mushroom that impart flavours when the mushroom is cooked. Its preparation should permit increased understanding of its chemical conversions to the flavours of the mushroom.****3. We propose to expand our already established sulfur chemistry tools to create new ligands. Ligands are compounds that can facilitate metal-catalyzed carbon-carbon bond forming reactions in a myriad of reactions. We will then be in a position to follow our ligand preparation and execute those carbon-carbon bond forming reactions so molecules can be constructed special stereochemical features.***