A wearable, textile-based platform for the rapid detection of bacteria in urine.

可穿戴设备（如FitbitTM）有助于实时监控一个人的生命统计数据。更进一步，这种装置可以用来监测感染、伤口愈合或身体对药物的反应。在这个项目中，我们将开发一种可穿戴的、基于纺织品的传感器来监测细菌败血症，主要用于老年患者尿路感染的诊断。尿路感染通常是有症状的诊断，并使用广谱药物治疗，这可能导致抗生素耐药性和慢性感染的发展[2,3]。在老年人中，这可能导致慢性或危及生命的疾病，并随后导致患者生活质量下降。我们计划开发的设备将完全由纺织材料制成，并且可以方便地放入患者的衣服中。该设备的分析将通过创新的过滤和免疫测定介导的方法，帮助在计量量的患者尿液中识别细菌病原体。因此，我们希望能够预防感染的发生，并有可能帮助**确定合适的治疗方案。王杰，王杰。非侵入式可穿戴电化学传感器研究进展。生物技术进展，32,**363371(2014).**2。Rowe, t.a.和Juthani-Mehta， M.老年人尿路感染的诊断和管理。感染,* *说。中国。中国农业大学学报（自然科学版），2014,32(1).** 2。Kline， K. A. & Bowdish， D. M. E. science《老龄人口的直接感染》。咕咕叫。当今。微生物学报，29,**6367（2016）。

Wearable devices (such as the FitbitTM) help monitor a persons vital statistics in real time. Taken a step further,**such devices may be used to monitor infections, wound-healing, or the bodys response to a pharmaceutical drug**[1]. In this project, we will develop a wearable, textile-based sensor to monitor bacterial sepsis, primarily for the**diagnosis of urinary tract infections in geriatric patients. Urinary tract infections are often diagnosed**symptomatically, and treated with broad spectrum drugs, which can lead to the development of antibiotic**resistance and chronic infection [2,3]. In the elderly, this can result in chronic or life-threatening conditions [3]**and a subsequent decline in the patients' quality of life. The device we propose to develop, will be made entirely**from textile-based materials, and will fit conveniently into the patients clothing. The analysis from the device will**help identify a bacterial pathogen in a metered amount of the patient's urine via an innovative filtration and**immunoassay-mediated approach. We thereby hope to preempt the onset of infection, and potentially aid in**determining an appropriate course of treatment.**1. Bandodkar, A. J. & Wang, J. Non-invasive wearable electrochemical sensors: A review. Trends Biotechnol. 32,**363371 (2014).**2. Rowe, T. A. & Juthani-Mehta, M. Diagnosis and Management of Urinary Tract Infection in Older Adults. Infect.**Dis. Clin. North Am. 28, 7589 (2014).**3. Kline, K. A. & Bowdish, D. M. E. ScienceDirect Infection in an aging population. Curr. Opin. Microbiol. 29,**6367 (2016).