课题基金 / 基金详情

High-Resolution Modeling in Systems Biology

High-Resolution Modeling in Systems Biology
系统生物学中的高分辨率建模
批准号:
CRC-2015-00042
负责人:
Xia, Yu
金额:
$14.57万
依托单位:
依托单位国家:
加拿大
项目类别:
Canada Research Chairs
财政年份:
2018
资助国家:
加拿大
项目状态:
已结题
起止时间:
2018-01-01 至 2019-12-31

项目摘要

项目成果

Xia, Yu的其他基金

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中文摘要
翻译
CRC在系统生物学高分辨率建模方面的研究项目旨在为真核生物模型物种、人类和不同物种蛋白质之间的蛋白质-蛋白质相互作用网络中的节点和边缘构建精确的、基因组尺度的、原子分辨率的三维结构模型。这是通过开发高分辨率系统生物学的关键计算技术,并与领先的实验系统生物学家合作来实现的。这些高分辨率的细胞电路模型将用于探索生物网络的设计原则,并阐明人类传染病和遗传疾病的系统级机制
英文摘要
The research program of the CRC in High-Resolution Modeling in Systems Biology aims to construct accurate, genome-scale, atomic-resolution three-dimensional structural models for nodes and edges within protein-protein interaction networks in model eukaryotic species, in human, and between proteins from different species. This is achieved by developing key enabling computational technologies for high-resolution systems biology, and by collaborating with leading experimental systems biologists. These high-resolution models of cell circuitry will be used to probe design principles of biological networks, and to elucidate systems-level mechanisms of both human infectious and genetic diseases.*
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会议论文
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
  • 批准号:
    RGPIN-2019-05952
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.64万
  • 财政年份:
    2022
  • 负责人:
    Xia, Yu
  • 依托单位:
Computational and Systems Biology
  • 批准号:
    CRC-2021-00424
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Xia, Yu
  • 依托单位:
High-Resolution Modeling in Systems Biology
  • 批准号:
    CRC-2015-00042
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $7.29万
  • 财政年份:
    2022
  • 负责人:
    Xia, Yu
  • 依托单位:
Using Structural Systems Biology Modelling to Probe High-Resolution Design Principles of Protein Networks
  • 批准号:
    RGPIN-2019-05952
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $3.64万
  • 财政年份:
    2021
  • 负责人:
    Xia, Yu
  • 依托单位:
国内基金
海外基金
Galaxy Analytical Modeling Evolution (GAME) and cosmological hydrodynamic simulations.
  • 批准号:
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2025
  • 负责人:
    Antonios Katsianis
  • 依托单位: