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Manipulating IL-15 and TGFb signaling augments Natural Killer cell homeostasis and protects from experimental pulmonary arterial hypertension

Manipulating IL-15 and TGFb signaling augments Natural Killer cell homeostasis and protects from experimental pulmonary arterial hypertension
操纵 IL-15 和 TGFb 信号传导增强自然杀伤细胞稳态并预防实验性肺动脉高压
批准号:
411933
负责人:
Ratsep Matthew T
金额:
$0.07万
依托单位国家:
加拿大
项目类别:
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-09-01 至 2020-09-01

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中文摘要
翻译
肺动脉高压(PAH)导致肺部血管变窄和丧失,导致心脏压力增加,并因心力衰竭而死亡。PAH的治疗费用昂贵,而且在症状方面对患者几乎没有好处
英文摘要
Pulmonary arterial hypertension (PAH) causes narrowing and loss of blood vessels in the lungs, leading to increased stress on the heart and death by heart failure. Treatments for PAH are expensive and provide little benefit to the patient in terms of symp
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A novel therapeutic approach to pulmonary arterial hypertension - targeting natural killer cells through the interleukin-15 and transforming growth factor-beta pathways.
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