Advanced Cell-instructive Materials and Biotherapeutics

可注射水凝胶有可能给微创药物输送和3D生物打印带来革命性的变化，3D生物打印是组织和器官的自动化生产。然而，传统水凝胶的有效性仍然受到其次优机械性能的限制。保罗博士的研究计划将通过开发一种新型纳米复合水凝胶来满足这些需求，该水凝胶具有高结构稳定性、可印刷性和提供持续治疗药物的能力。这种新的材料设计将使生物组织的工程成为可能，其形状和生物活性可以根据患者的具体情况而定。

Injectable hydrogels have the potential to revolutionize both minimally invasive drug delivery, and 3D bioprinting, the automated production of tissues and organs. However, the effectiveness of conventional hydrogels is still limited by their suboptimal mechanical properties. Dr. Pauls research program will address these needs by developing a new class of nanocomposite hydrogels with high structural stability, printability, and ability to provide sustained delivery of therapeutics. This new material design will enable the engineering of living tissues whose shapes and biological activities can be patient-specific.