Eukaryotic Cellular Signaling

多细胞生物体依赖于信号转导级联来控制重要的生物反应，例如细胞生长、分化和存活。了解这些蛋白质-蛋白质相互作用的生化基础对于确定特定突变如何导致病理状况至关重要。该研究计划使用多学科方法来研究细胞通讯的分子机制。这项研究是了解发育，肾功能，血管形成和神经系统模式方面的前沿和基础，这些发现可能最终有助于建立肾脏疾病和癌症等人类病理学的新治疗策略。

Multicellular organisms rely on signal transduction cascades to control important biological responses such as cell growth, differentiation and survival. Understanding the biochemical basis of these protein-protein interactions is of key importance in defining how particular mutations can contribute to pathological conditions. This research program uses a multi-disciplinary approach to investigate the molecular mechanisms that underlie cellular communication. This research is cutting edge and fundamental to understanding aspects of development, kidney function, blood vessel formation and nervous system patterning, and the discoveries may ultimately contribute to the establishment of new treatment strategies for human pathologies such as renal disease and cancer.