Urgent Replacement of 700 MHz NMR CryoPlatform

最多3000个字符***剩余字符：71******急需所需的冷冻平台来修复和升级我们宝贵的700 MHz核磁共振光谱仪。为这种设备提供的资金将恢复在催化、药物化学、能量收集、纳米技术和材料科学等各个领域做出高影响力发现和培养高素质人才（HQP）的努力。在过去的12年里，磁共振区域中心的700兆赫冷冻探针核磁共振光谱仪每月运行420至500小时，是化学系（universit<s:1> de montracimal） 20位教授实验室的200名学生和博士后（pdf）所使用的重要分析工具。2019年8月，关键低温平台的组件发生故障。如果没有所要求的部件，700 MHz核磁共振光谱仪的灵敏度就会降低，无法满足最初购买的160万美元机器的需求。加拿大在药物化学、催化和材料科学方面的领先实验室的研究已被推迟，影响了针对药物发现、绿色制造和下一代太阳能电池和电池的多个跨学科合作项目。12个申请人包括低温探针700 MHz核磁共振光谱仪的所有主要用户。申请人目前管理115名学生，pdf和访问科学家，其中50%是女性，30%是少数族裔。低温平台的紧急维修对这些申请人来说至关重要，他们承担着维持生产力的沉重负担，并定期与多个外部合作者分享结果。年轻研究人员的职业轨迹也停滞不前，因为他们无法获得冷冻探针700 MHz核磁共振波谱仪来推进化学糖组学和光催化的研究，也无法获得ACS石油研究基金等机构的竞争性资助。此外，低温平台的故障已经危及了来自大学以外的其他学术和私营部门实验室的十几个客户的项目。配备低温探针的700兆赫核磁共振仪器已成为当今学术界和工业界所需领域培训HQP的最先进的教学设备。各种区域范围的学生项目依赖于低温探针700兆赫核磁共振光谱仪的高灵敏度来研究溶液中的少量复杂分子。我们迫切需要恢复我们的冷冻探针700 MHz核磁共振光谱仪的全部功能，以获取复杂分子结构的精确信息，以保持有价值的科学研究的稳定流动，培养HQP，并领导生物药物化学，绿色化学/催化和材料科学方面的合作项目，以确保加拿大的经济活力和高水平的生活。********

3000 characters maximum ***Characters remaining:71******The requested cryoplatform is urgently needed to repair and upgrade our valuable 700 MHz NMR spectrometer. Funding for this equipment would restore efforts to make high impact discoveries and train highly qualified personnel (HQP) in various fields including catalysis, medicinal chemistry, energy harvesting, nanotechnology and materials science. An essential analytical tool that was used by >200 students and postdoctoral fellows (PDFs) from the laboratories of >20 professors in the Department of Chemistry (Université de Montréal), the cryoprobe 700 MHz NMR spectrometer has operated between 420 to 500 h/month over the past 12 years in the Regional Centre for Magnetic Resonance. Components of the essential cryoplatform failed in August 2019. Without the requested parts, the 700 MHz NMR spectrometer is less sensitive and incapable of serving the needs for which the $1.6 million machine was originally purchased. Research in the laboratories of Canadian leaders in medicinal chemistry, catalysis, and materials science has since been delayed, impacting upon multiple interdisciplinary collaborative projects targeted on drug discovery, green-manufacturing and next-generation solar cells and batteries. The 12 applicants include every primary user of the cryoprobe 700 MHz NMR spectrometer. The applicants supervise currently 115 students, PDFs and visiting scientists of which 50% are female and 30% are visible minorities. Urgent repair of the cryoplatform is critical to these applicants, who carry heavy burdens to sustain productivity and share results on a regular milestone basis with multiple external collaborators. Career trajectories of young investigators are also being stalled without access to cryoprobe 700 MHz NMR spectrocopy to advance research in chemical glycomics and photocatalysis, with competitive funding from agencies such as the ACS Petroleum Research Fund. Moreover, cryoplatform failure has jeopardized projects with over a dozen clients from outside the university in other academic and private sector laboratories. The cryoprobe-equipped 700 MHz NMR instrument has been a state-of-the-art teaching device for training HQP in an area required for contemporary research in academia and industry worldwide. Various region-wide student projects depend on the high sensitivity of the cryoprobe 700 MHz NMR spectrometer to study small quantities of complex molecules in solution. Restoration of the full functionality of our cryoprobe 700 MHz NMR spectrometer is urgently needed for procuring precise information on complex molecular structures to maintain a steady flow of valuable scientific research, to train HQP, and to lead collaborative projects in bio-medicinal chemistry, green chemistry/catalysis, and materials science needed to ensure economic vitality and a high standard of living in Canada.********