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Environmental Radiobiology

Environmental Radiobiology
环境放射生物学
批准号:
CRC-2017-00228
负责人:
Mothersill, Carmel
金额:
$14.57万
依托单位:
依托单位国家:
加拿大
项目类别:
Canada Research Chairs
财政年份:
2019
资助国家:
加拿大
项目状态:
已结题
起止时间:
2019-01-01 至 2020-12-31

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中文摘要
翻译
本提案旨在研究辐射诱导的旁观者信号和辐射与物质初始相互作用后的下游事件的物理传输的现象学和机制。我们已经证明,初始事件的发生不需要在细胞之间转移或共享液体介质,从而排除了完全的化学机制。该建议的主要目的是阐明信号转导中涉及的生物物理、生化和生物能量学途径,但其结果应确定辐射保护和癌症治疗的新靶点,并应导致放射生物学的新概念。
英文摘要
This proposal seeks to investigate the phenomenology and mechanisms involved in the physical transmission of radiation induced bystander signals and downstream events subsequent to the initial interaction of radiation with matter. We have demonstrated that the initial events occur without the need for transfer or sharing of liquid medium between cells precluding a wholly chemical mechanism. The elucidation of biophysical, biochemical and bioenergetics pathways involved in signal transduction is the main objective of the proposal, however the results should identify new targets for radiation protection and for cancer therapy and should result in new concepts in radiobiology.
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Environmental Radiobiology
  • 批准号:
    CRC-2017-00228
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $14.57万
  • 财政年份:
    2022
  • 负责人:
    Mothersill, Carmel
  • 依托单位:
Physical transmission of bystander signals following ionising radiation exposure
  • 批准号:
    RGPIN-2017-06223
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $5.25万
  • 财政年份:
    2021
  • 负责人:
    Mothersill, Carmel
  • 依托单位:
Environmental Radiobiology
  • 批准号:
    CRC-2017-00228
  • 项目类别:
    Canada Research Chairs
  • 资助金额:
    $14.57万
  • 财政年份:
    2021
  • 负责人:
    Mothersill, Carmel
  • 依托单位:
Physical transmission of bystander signals following ionising radiation exposure
  • 批准号:
    RGPIN-2017-06223
  • 项目类别:
    Discovery Grants Program - Individual
  • 资助金额:
    $2.62万
  • 财政年份:
    2020
  • 负责人:
    Mothersill, Carmel
  • 依托单位:
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