Rampable Intraoperative Magnetic Resonance Imaging

核磁共振扫描仪生成大脑和脊髓解剖和病理的精致详细图像。虽然 这是一项工程挑战，在手术室放置核磁共振系统将彻底改变神经外科。 关心。第一个商用iMRI系统是由GE与Brigham基于0.5特斯拉磁铁开发的 和波士顿的妇女医院。1988年，温尼伯(IMRIS)的一个研究小组开发了一种基于 1.5特斯拉磁铁，克服了GE系统发现的许多难题。IMRI 技术使神经外科医生能够改善手术和结果。术中核磁共振还发现了一个 有相当数量的患者在手术结束时有意外的肿瘤残留，因此避免了 他们的不适和重新手术的费用。 作为市场领先者的IMRIS术中系统的主要问题是过于昂贵。 一个更严重的问题是，医院的翻新费用要昂贵得多，而且 在这次翻修期间，需要关闭几个月的运营套房。 我们的新概念是将iMRI建立在无低温磁体的基础上，该磁体可以倾斜到1特斯拉，并稳定在 在10分钟内完成这一任务。磁体将由二硼化镁(Mgb2)制成，这是一种很高的 温度超导材料。磁铁将不断地连接到电源上，因此也将 考虑到快速斜坡率，不需要持久。 新设计目标是有一个术中核磁共振需要2周来安装在一个标准的 医院外科套件，可在2012年提供与1.5Tesla商用MRI相同质量的图像 同一时间。在这项建议中正在开发的重要研究因素是获得图像质量 与1.5特斯拉综合管理信息系统所获得的结果相当或更好。众所周知，信号到 噪声比(SNR)随场强呈线性增加，因此1特斯拉磁铁将有大约60%的SNR 1.5特斯拉磁铁。我们将开发射频线圈和人工智能技术来提高图像质量。

MRI scanners generate exquisitely detailed images of brain and spinal cord anatomy and pathology. Although an engineering challenge, the placement of MRI systems in the operating room will revolutionize neurosurgical care. The first commercial iMRI systems were developed by GE based on a 0.5 Tesla magnet with Brigham and Women's hospital in Boston. In 1988 a group in Winnipeg (IMRIS) developed an iMRI system based on a 1.5 Tesla magnet which overcame many of the difficult issues discovered with the GE system. The iMRI technology enabled neurosurgeons to improve surgeries and outcomes. Intraoperative MRI has also identified a significant number of patients who harboured unsuspected, residual tumour at the end of surgery, thus sparing them the discomfort and expense of reoperation. The major problem with the IMRIS intraoperative system which is the market leader it was is too expensive. An even more serious problem was that the cost of renovation to the hospital was much more expensive and required operating suites to be closed for months during this renovation. Our new concept is to base the iMRI on a cryogen free magnet which can be ramped to 1 tesla and is stable at this field in 10 minutes. The magnet will be made with Magnesium Diboride (MgB2) which is a high temperature superconducting material. The magnet will be continually connected to a power supply and so will not require to be persistent allowing for the rapid ramp rate. The objective of the new design is to have an intra-operative MRI that take 2 weeks to install in a standard hospital surgical suite which can provide images of the same quality as a 1.5 Tesla commercial MRI on 2012 in the same time. The important research factor being developed in this proposal is to obtain image quality equivalent or better to what was obtained with the 1.5 tesla IMRIS systems. It is well known that the signal to noise ratio (SNR) increases linearly with field strength so a 1 Tesla magnet will have about 60% of the SNR to that of 1.5 Tesla magnet. We will develop RF coils and AI techniques to improve image quality.