IFlowPlate - A universal platform for vascularizing organoids

生物研究，包括学术实验室的基础研究、制药公司的药物发现和医院的临床研究，都需要可预测的生物模型。近年来，有机化合物的出现在学术研究和商业领域引起了极大的关注。类有机器官是从单个或一小群人类干细胞随着时间的推移在培养皿中培养出来的微型器官。尽管有机化合物不能取代人类，但它们可以为药物的功能、疾病进展的机制以及器官发育过程提供有价值的见解，这是单细胞分析或动物模型无法提供的。然而，在所有有机化合物中都缺少一个关键的生物成分--可灌流的血管网络。为了解决这个问题，我们开发了一个平台(这里称为IFlowPlatform)，它可以用来培养一系列可灌流的血管网络，以按需使有机物质血管化 我们IFlowplate平台的商业化是为了为学术、制药和医院实验室提供一个更具生理学的模型，以及一种通过用血管系统升级现有器官培养物来探索血管内灌流模型的方法。我们计划通过围绕IFlowPlatform建立一个由合作者和测试者组成的生态系统来实现IFlowPlatform的商业化，以持续验证我们的产品并扩大其应用。申请的市场评估资金将提供建议和数据，使我们能够为成功的技术转让和市场定位创建产品开发和业务。

Biological research, which encompasses fundamental research in academic labs, drug discovery in pharmaceutical companies, and clinical research in hospitals requires predictable biological models. In recent years, organoids has emerged and attracted significant attention in academic research as well as in the commercial sectors. Organoids are mini organs that are grown in a dish over time from a single or a small cluster of human stem cells. Though organoids cannot replace humans, they can offer valuable insights into the function of drugs, the mechanism of disease progression, and the process of organ development that cannot be provided by single-cell assay or animal models. However, there is one critical biological component that is missing in all organoids - a perfusable blood vessel network. To solve this problem, we developed a platform (here referred to as IFlowPlate) that can be used to grow an array of perfusable blood vessel network to vascularize organoids on demand Commercialization of our IFlowPlate platform is to provide academic, pharmaceutical and hospital lab with a more physiological model and a way to probe the model with intravascular perfusion by upgrading existing organoid cultures with vasculatures. We propose to commercialize the IFlowPlate by establishing an ecosystem of collaborators and beta testers around IFlowPlate to continuously validate our product and expand its application. The requested funds for a Market Assessment will provide recommendations and data to enable us to created a product development and business for successful technology transfer and positioning in the market.