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ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension

ATP Citrate Lyase: an attractive target at the nexus of metabolic and epigenetic alterations in pulmonary arterial hypertension
ATP 柠檬酸裂解酶:肺动脉高压代谢和表观遗传改变之间的一个有吸引力的靶标
批准号:
450668
负责人:
Boucherat Olivier
金额:
$54.06万
依托单位:
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2021
资助国家:
加拿大
项目状态:
未结题
起止时间:
2021-09-01 至 2026-09-01

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中文摘要
翻译
患有肺动脉高压的患者具有构成其肺中动脉壁的细胞的功能障碍。像癌细胞一样,PAH细胞的特征是过度增殖和抵抗死亡的能力,从而导致肿瘤的发生。
英文摘要
Patients with pulmonary arterial hypertension have a dysfunction of the cells constituting the wall of their arteries in the lungs. Like cancer cells, PAH cells are characterized by exaggerated capacity to multiply and resistance to death resulting in a p
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会议论文
Role of the long non-coding RNA H19 as a novel biomarker and therapeutic target in right ventricular failure in pulmonary arterial hypertension
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