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Preventing organ failure in sepsis by NAD(+) repletion: mechanistic insights and therapeutic potential

Preventing organ failure in sepsis by NAD(+) repletion: mechanistic insights and therapeutic potential
通过补充 NAD() 预防脓毒症中的器官衰竭：机制见解和治疗潜力
批准号：
450507
负责人：
Peng Tianqing
金额：
$51.83万
依托单位：
University of Western Ontario
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2021
资助国家：
加拿大
项目状态：
未结题
起止时间：
2021-09-01 至 2026-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=450507&lang=en
关键词：
Cardiomyocytes Lysosomal Dysfunction Macrophages Mitochondrial Dysfunction Mitochondrial Ros Nad+ Neutrophils Nicotinamide Mononucleotide Sepsis Sirtuin 3

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中文摘要
翻译
败血症是一种危及生命的器官功能障碍，由宿主对感染的反应失调引起。这一直是重症监护中最重大的挑战之一。据估计，2017年有4880万例病例和1100万例败血症相关病例
英文摘要
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. It has been one of the most significant challenges in critical care. It was estimated that in 2017 there were 48.8 million cases and 11 million sepsis-rela
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