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Pairing pooled CRISPR/Cas9 screens with high-resolution multiplexed approaches to study cell competition and pre-malignancy in breast and skin epithelium

Pairing pooled CRISPR/Cas9 screens with high-resolution multiplexed approaches to study cell competition and pre-malignancy in breast and skin epithelium
将混合 CRISPR/Cas9 筛选与高分辨率多重方法配对，研究乳腺和皮肤上皮细胞的细胞竞争和癌前病变
批准号：
458127
负责人：
Teng Katie
金额：
$7.65万
依托单位：
Sinai Health System (Toronto)
依托单位国家：
加拿大
项目类别：
Studentship Programs
财政年份：
2021
资助国家：
加拿大
项目状态：
已结题
起止时间：
2021-11-01 至 2024-11-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=458127&lang=en
关键词：
Breast Cancer Cell Competition Crispr/Cas9 Functional Genomics Genetics Imaging Mass Cytometry Pre-Malignancy Single-Cell Spatial Phenotyping Skin Cancer Tumour Immune Microenvironment

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中文摘要
翻译
许多健康的成人组织，如乳房和皮肤，都含有携带突变的细胞，这些突变随着年龄的增长而积累，并与癌症的发展有关。虽然已知许多细胞在正常组织中发生突变，但细胞竞争等机制
英文摘要
Many healthy adult tissues, such as the breast and skin, contain cells that carry mutations that accumulate with age and are linked to cancer development. Although many cells are known to be mutated in normal tissues, mechanisms such as cell competition a
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Loss-of Lkb-1 in oviductal epithelium facilitates initiation and progression of High grade serous ovarian carcinoma
  • 批准号：
    378842
  • 项目类别：
    Studentship Programs
  • 资助金额：
    $1.27万
  • 财政年份：
    2016
  • 负责人：
    Teng Katie
  • 依托单位：
    McGill University
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