Mechanisms of IRF2-driven immune regulation in the tumor microenvironment
Mechanisms of IRF2-driven immune regulation in the tumor microenvironment
批准号:
461659
负责人:
Brooks David
金额:
$81.51万
依托单位国家:
加拿大
项目类别:
Operating Grants
财政年份:
2022
资助国家:
加拿大
项目状态:
未结题
起止时间:
2022-03-01 至 2027-03-01
中文摘要
促进肿瘤生长的肿瘤微环境(TME)中的免疫改变的中心是CD8 T细胞的功能衰减(耗尽)。 因此,恢复CD8 T细胞的功能,使它们能够消除肿瘤是目前的主要研究方向。
英文摘要
Central to immune alterations in the tumor microenvironment (TME) that facilitate tumor growth is the functional attenuation (exhaustion) of CD8 T cells. As a result, restoring function to CD8 T cells so that they can eliminate tumors is currently a main
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会议论文
Type I interferon mediated regulation of chronic virus infection
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批准号:487143
-
项目类别:Operating Grants
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资助金额:$7.29万
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财政年份:2023
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负责人:Brooks David
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依托单位:
Type I interferon mediated regulation of chronic virus infection
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批准号:487980
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项目类别:Operating Grants
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资助金额:$90.0万
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财政年份:2023
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负责人:Brooks David
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依托单位:
Immune Regulation during Chronic Disease
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批准号:333485
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项目类别:Operating Grants
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资助金额:$370.19万
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财政年份:2015
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负责人:Brooks David
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依托单位:
海外基金