Influence of immunotherapy with interferon-alpha and the efficacy of interferon combined with dendritic therapy on renal cell carcinoma

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We examined the efficacy of immunotherapy combined with cytokines (IFN-a and IL-2) and the impact of the immunotherapy on host immunity in RCC patients. We found that regulatory T cells result in inducing negative effect in recipients received with immunotherapy such as cytokine-therapy or nonmyeloablative allogeneic cell therapy. We also indicated that targeted drugs- or dendritic cells-therapy combined with IFN-a administration is feasible and safe, and the treatment has the potential for prolonging the time to progression in advanced RCC.