New Methods for the Stereoselective Synthesis of Organic Compounds

在有机合成中，大量成功的方法已经达到了令人印象深刻的数字，但要用对环境影响最小的高效方法合成任何分子，还有很长的路要走。我们研究的具体目标是开发新的和有效的方法来选择性合成有机化合物。作为有机化学家，我们不仅努力改进现有的合成方法，而且努力开发新的、更有效的合成方法。为了达到这个效果，我们仍然需要更强大、更环保、不受保护的团体。有机化学的这一领域至关重要，因为今天在各种相关学科（制药、农用化学品、生物学、材料科学、生物化学、食品科学等）中需要对映体纯化合物。我们将开发新的工具来帮助控制特定化学转化的特异性。其中，高反应重氮试剂、环丙烷的合成和功能化、杂环的高效形成和新的酰胺合成方法是最重要的主题。作为绿色化学12原则之一的催化作用将在新方法的发展中发挥核心作用。我们还充分利用了一种叫做微反应器技术的技术，也被称为连续流动合成。这是一项新兴而强大的技术，可以使以前认为过于危险而不能“批量”进行的反应条件（高温，危险试剂等）成为可能。微反应器的多功能性允许安全，方便，快速生产从毫克到多克规模，而无需对反应方案进行重大修改。此外，该技术还可以将光化学和电化学转化结合起来，以连续的方式进行放大，这是一种非常困难甚至不可能批量实现的特性。我们的研究成果对学术和工业部门都非常重要，因为目标化合物是关键的中间体，将导致在上述各个领域开发新产品。考虑到一些化学相关的公司都在大蒙特利尔地区，我们预计我们的研究将自然地加强和补充他们现有的研发项目，从而帮助他们磨练他们在全球经济中的竞争优势。同时，在有机化学和绿色实践方面拥有独特技能和现代思维的新一代高素质科学家将得到完美的培训，以加入劳动力队伍，并确保独特的专业知识流入市场。此外，从我们的研究中产生的潜在发现将打开创新的大门，最终将为加拿大人民创造一个更健康、更清洁的环境。

The plethora of successful methodologies available in organic synthesis has reached an impressive number, but there is still a long way to go to synthesize any molecule using highly efficient methods having minimal environmental impact. The specific aim of our research will be directed towards the development of new and efficient methods for the selective synthesis of organic compounds. As organic chemists, we always strive not only to improve existing synthetic methods, but also to develop new and more effective ones. To that effect, more powerful, greener, and protecting-group-free are still needed. This area of organic chemistry is of primary importance due to today's necessity for enantiomerically pure compounds in a variety of related disciplines (pharmaceuticals, agrochemicals, biology, material sciences, biochemistry, food sciences, etc.). We will develop novel tools to help control the specificity of a given chemical transformation. Among the priorities, highly reaction diazo reagents, cyclopropane synthesis and functionalization, highly efficient formation of heterocycles, and novel amide synthesis procedures are the most important themes. Catalysis, which is featured as one of the 12 principles of Green chemistry will play a central role in the development of new methods. We are also taking full advantage of a technique called micro reactor technology also known as continuous flow synthesis. This is an emerging and powerful technique that enables reaction conditions previously thought to be too hazardous to be carried out in "batch" (high temperature, hazardous reagents, etc.). The versatility of the micro reactors allows the safe, facile, and rapid production from mg to multi-gram scale without significant modification of the reaction protocol. Furthermore, this technique also enables the incorporation of photochemical and electrochemical transformations for the scale-up in continuous fashion, a feature that is very difficult or even impossible to achieve in batch. The fruits of our research will be extremely important for both the academic and industrial sectors, because the target compounds are critical intermediates that will lead to the development of new products in the various fields stated above. Considering that several chemistry-related companies are based in the greater Montreal area, we anticipate that our research will naturally strengthen and complement their existing R&D programs, thus help them hone their competitive edge in the global economy. As well, a new generation of highly qualified scientists possessing unique skills and a modern mindset on organic chemistry and green practices will be perfectly trained to join the workforce and to ensure a flow of unique expertise into the marketplace. In addition, the potential for discoveries that will emerge from our research will open the door to innovation, which, ultimately, will create a healthier and cleaner environment for the Canadian population at large.