Role of brain dimensionality in altered states of consciousness.

我们正在进入一个不同科学学科之间前所未有的互动时代，以解开大脑的奥秘，比如意识，这需要许多神经元在一个高度复杂的互动架构中组织起来的集体行为。远程动力学对于描述皮质区域如何相互作用和提取大脑维度是必不可少的。这涉及到设想超越3维物理空间的新的度量空间，并且在理解空间维度如何塑造信息流方面起着基本作用。大脑动力学的数值模拟和建模达到了新的现实水平，意识理论也变得更加复杂。我的长期探索项目目标是通过开发更真实的清醒状态和不同意识改变状态（如睡眠）下自发和受刺激的大脑活动模型，保持我在脑动力学研究中的领先地位。我未来五年的短期目标是：1)发展一个更现实的广义Ising模型（Generalized Ising Model， GIM），通过结构连接、代谢或脑电图活动来预测清醒状态和意识改变状态（如睡眠）下的自发大脑活动。2)在清醒状态和改变的意识状态下，通过参与自然的听觉输入来表征受刺激的活动。我将修改开发的GIM，通过添加一个外部磁场来预测自发活动，并通过音频剪辑提取剖面来模拟刺激的效果。3)确定在有和没有外部磁场的情况下，GIM在清醒和意识改变状态下的临界行为。我将计算每个意识层次的系统维度，并研究其作用，以了解清醒和睡眠状态下的信息流。最后，我将计算有和没有外部磁场的发达GIMs的综合信息和因果密度，以表征不同的意识水平。将研究因果相互作用对系统维数的依赖性。新的策略将被开发出来，以研究意识的神经相关物在大脑进化中的作用。我有许多国际合作，并期望积极参与神经科学社区，为模拟大脑的长期动态和理解支持意识的机制贡献新的见解。

We are entering an era of unprecedented interaction between different scientific disciplines to unravel the mysteries of the brain such as consciousness, which requires the collective behavior of many neurons organized in a highly sophisticated interactive architecture. Long -range dynamics are essential to describe how cortical areas interact and to extract brain dimensionality. This involves envisioning new metric spaces beyond the 3--dimensional physical space, and plays a fundamental role in understanding how space dimensionality shapes information flow. Numerical simulations and modeling of brain dynamics are reaching new levels of realism, and theories of consciousness are becoming more sophisticated. My long -term Discovery program objective is to maintain my leading role in brain dynamics research through the development of more realistic models of spontaneous and stimulated brain activity during wakefulness and in different states of altered consciousness such as sleep. My short- term objectives for the next five years are: 1) to develop a more realistic Generalized Ising Model (GIM) to predict spontaneous brain activity from structural connectivity and metabolic or encephalography activity in wakefulness and altered states of consciousness such as sleep. 2) To characterize stimulated activity using engaging naturalistic auditory input in wakefulness and in altered states of consciousness. I will modify the developed GIM to predict spontaneous activity by adding an external magnetic field with a profile extracted by the audio clip to model the effect of stimulation. 3) To determine the critical behavior of the GIM with and without an external magnetic field in wakefulness and altered states of consciousness. I will calculate dimensionality of the system for each level of consciousness and its role investigated to understand information flow in awake and under sleep. Finally I will calculate integrated information and causal density for the developed GIMs with and without an external magnetic field to characterize the different levels of consciousness. The dependence of causal interaction on the system's dimensionality will be investigated. New strategies will be developed to investigate the role of neural correlates of consciousness in the evolution of the brain. I have many international collaborations in place and expect to participate actively in the neuroscience community to contribute new insights into modeling the long -range dynamics of the brain and to the understanding of the mechanisms that support consciousness.