Electrochemically-driven Chan-Lam coupling reactions

制药和农化研究的成功很大程度上取决于快速有效地构建新分子以测试多种可能成分的能力。构建分子的关键要求之一是在分子的特定点上引入杂原子。2010年，钯催化偶联反应获得诺贝尔奖，表彰了这些反应如何使复杂分子的构建变得更容易。然而，由于其高毒性，特别是对于药物来说，即使少量残留的钯存在也是有问题的。铜催化的Chan-Lam反应为钯催化的偶联反应提供了一种无毒的替代品，并且具有在较温和的条件下工作的额外优势。目前的项目将通过将定制设计的催化剂与控制的电化学驱动力相结合，提高Chan-Lam耦合的使用、灵活性和可靠性。

Success in pharmaceutical and agrochemical research depends strongly on the ability to construct new molecules fast and efficiently to test a multitude of possible components. One of the key requirements in building molecules is to introduce heteroatoms at specific points of the molecule. The Noble prize for Palladium-catalyzed coupling reactions in 2010 recognized how these reactions made the construction of complicated molecules easier. However, in particular for medications the presence of even small amounts of remaining Palladium is problematic due to its high toxicity. Copper-catalyzed Chan-Lam reactions offer a non-toxic alternative to Palladium-catalyzed coupling reactions and have the additional advantage to work at milder conditions. The current project will increase the use, flexibility and reliability of Chan-Lam couplings by combining custom-designed catalysts with a controlled electrochemical driving force for the reaction.