Pain Neuroimaging

疼痛是一种生物-心理-社会体验，但大多数研究只关注生物领域，不能令人满意地解释疼痛体验。与疼痛一样，身体意象是个体对身体大小、形状和特征的主观体验，是由生物、心理和社会文化构成的；因此，身体意象障碍在多种疾病中被报道为慢性疼痛障碍。尽管有这种联系，但身体形象和慢性疼痛之间的关系尚不清楚。莫耶迪教授提出的研究将加深我们对疼痛和身体形象交集的理解，并确定新的治疗靶点。通过解决两个研究主题。第一个主题将确定身体形象和疼痛体验之间的关系，使用改变个人身体形状和大小的视觉错觉(例如，手指伸展错觉)。这个主题包括三个目标，它们将(1)确定与手指伸展错觉相关的大脑区域；(2)确定通过视觉错觉对身体图像的改变是否会改变对疼痛实验模型的敏感性；以及(3)因果确定身体图像涉及的大脑区域会影响对实验疼痛模型的敏感性。这将为与身体形象障碍相关的慢性疼痛确定潜在的新治疗目标。主题2将决定手术后疼痛和身体形象变化的关系。这一主题包括三个目标：(3)探索变性人和顺性女性的疼痛体验；(2)确定BPD和疼痛之间的关系；(3)BPD和疼痛关系的混合方法分析。本主题将调查接受预防性乳房切除术的顺式妇女和接受顶端手术的变性人的疼痛体验，结合定性访谈和定量方法，包括行为、心理物理和神经成像方法。作为第一个研究跨性别者的疼痛体验的疼痛研究，以及身体形象对顺性女性和跨性别者疼痛的影响，这项拟议的研究

Pain is a biopsychosocial experience, but most studies have focused solely on the biological domain, which cannot satisfactorily explain the pain experience. Like pain, body image, an individual's subjective experience of the size, shape, and features of their body, is biologically, psychologically, and socio-culturally constituted; accordingly, disturbances of body image have been reported in multiple disorders chronic pain disorders. Despite this connection, the relationship between body image and chronic pain has yet to be understood. Prof. Moayedi's proposed research will deepen our understandings of the intersection of pain and body image and identify novel therapeutic targets. by addressing 2 themes of research. The first theme will determine the relationship between body image and the pain experience using visual illusion that change the shape and size of an individual's body (e.g, a finger stretch illusion). This theme comprises three objectives which will (1) identify brain regions causally involved in finger stretch illusion; (2) determine whether changes to body image through the visual illusion alter sensitivity to an experimental model of pain; and (3) causally determine which brain regions involved in body image affect sensitivity to an experimental model of pain. These would identify potential new therapeutic targets for chronic pains associated with body image disturbances. Theme 2 will determine the relationship post-surgical pain and changes in body image. This theme comprises three objectives that will (3) explore the pain experience in transmen and cisgender women; (2) determine the relationship between BPD and pain; and (3) a mixed method analysis of BPD and pain relationship. This theme will investigate the pain experiences of ciswomen undergoing prophylactic mastectomy and transmen undergoing top surgery combining qualitative interviews with quantitative methods including behavioural, psychophysical and neuroimaging method. As the first pain study to investigate the pain experiences in transmen, and the impact of body image on pain in both ciswomen and transmen, the proposed research