Preparation and characterization of functional coatings on additively manufactured implants

骨植入物可能由于多种原因而失败，包括由诸如老化、骨质疏松症或糖尿病等潜在疾病引起的骨整合不良，或由于新骨生长不完全进入植入物（称为骨整合）。这导致疼痛和需要更换手术。在这项提案中，我们将使用新的材料工程制造方法来生产3D打印植入物，这些植入物包含独特的多孔几何形状，以促进植入物内部的新骨形成。此外，这项工作的一个关键重点将是开发和应用含有靶向改善骨再生的分子的逐层涂层，以改善植入物的效果。将使用先进的表面表征和电子显微镜对多孔植入物的制造技术和涂层方法进行优化和评价。通过开发先进的表征工具，可以进一步了解植入物与骨组织的相互作用，这些工具可以实现涂层植入物表面的高分辨率和3D视图以及与骨的相互作用。这将导致改善骨植入装置的应用在牙科和骨科的加拿大人在未来。

Bone implants may fail for a number of reasons, including poor integration into bone caused by underlying conditions such as aging, osteoporosis or diabetes, or due to incomplete new bone growth into the implant called osseointegration. This leads to pain and the need for replacement surgeries. In this proposal, we will use new materials engineering manufacturing methods to produce 3D-printed implants that contain a unique porous geometry to promote new bone formation inside of the implant. In addition, a key focus of this work will be the development and application of layer-by-layer coatings containing molecules targeted to improve bone regeneration to improve implant outcomes. The manufacturing techniques for the porous implants and coatings methods will be optimized and evaluated using advanced surface characterization with electron microscopy. The interaction of implants with bone tissue will be further understood through the development of advanced characterization tools that enable a high-resolution and 3D view of the coated implant surface and interaction with bone. This will lead to improved bone implant devices for applications in dentistry and orthopedics for Canadians in the future.