Development of a Nanowire Field Effect Transistor Biochemical Sensor

这是联盟- dnd计划的一项提案，旨在开发民用和军用两用传感器。我们建议开发基于InAs纳米线的小型化（便携式）、低成本、高效和选择性传感器，该传感器可以部署在水基和气基平台上，用于各种分析物。该项目是基于我们最近成功地展示了使用这种传感器检测乙醇蒸汽到单分子范围。我们在该项目的合作伙伴是加拿大国防研究与发展（DRDC）萨菲尔德研究中心和TeknoScan系统公司（TS）。当暴露在危险气体中时，具有区分多种物种能力的传感器可以作为最终用户的保护，或者在希望以前所未有的准确性识别特定分子的生物案例中使用。这种合作伙伴关系有潜力满足各种行业的应用，例如工业，农业或家庭安全的环境监测（例如NH3， CO2或H2S监测）；在国家安全和国防应用中检测有害污染物或化学战剂（CWAs）；作为溶液中生物传感器的生物标记物或疾病检测-在药物筛选和DNA测序中非常有用。这种传感器具有广泛的适用性和实用性，例如与区分样品分析物中的成分有关的分析技术或提高传感器灵敏度的方法，应该对许多加拿大工业有用。此外，传感器的好处还可以对环境、最终用户的整体福祉以及相关行业的金融繁荣产生积极影响。在该项目完成后，我们的合作伙伴TS将有办法构建自己的便携式测量系统，包括民用应用，如挥发性有机碳（VOCs）的检测，而DRDC将从现场使用和实施制造的设备中受益匪浅。合作伙伴将在5年内每年捐助20多万加元，这一项目将有利于加拿大的工业、我们的健康和环境，并将扩大到保护我们的士兵。

This is a proposal with the Alliance-DND program aimed at the development of sensors for dual use - both civilian and military use. We propose to develop miniaturized (portable), low-cost, efficient, and selective sensors based on InAs nanowires that can be deployed on both aqueous and gas-based platforms for a wide variety of analytes. The project is based on our recent success in demonstrating the use of such sensors to detect ethanol vapour down to the single molecule range. Our partners in the project are Defence Research and Development Canada (DRDC) Suffield Research Centre and TeknoScan Systems Inc. (TS). A sensor with the ability to distinguish multiple species can serve as a protection to the end-user when exposed to dangerous gases or hold use in biological cases where one wishes to identify specific molecules with unprecedented accuracy. This partnership has potential to satisfy applications in various industries such as environmental monitoring for industrial, agricultural, or home safety (e.g., NH3, CO2, or H2S monitoring); sensing of harmful contaminants or chemical warfare agents (CWAs) in national security and defense applications; detection of biomarkers or diseases as a biological in-solution sensor - with extreme usefulness in drug screening and DNA sequencing. Such sensors, having a wide range of applicability and practicality, such as analysis techniques related to distinguishing components in a sample analyte or methodologies to enhance sensor sensitivity, should prove useful for many Canadian industries. Moreover, the sensors benefits can also contribute to positive impacts on the environment, overall well-being of the end-users, as well as financial prosperity for the industries involved. Upon completion of this project, our partner, TS, will have the means to construct their own measurement systems for portable uses, including civilian applications such as detection of volatile organic carbons (VOCs) - while DRDC will benefit heavily from in-field use and implementation of the manufactured devices. The partners are contributing over $200K pa over 5 years, in a project that can benefit Canadian industry, our health and the environment, and be extended to the protection of our soldiers.