Biomechanical dose and real-time neurophysiological response during direct and whiplash head loading in humans

轻度创伤性脑损伤（mTBI），俗称脑震荡，每年影响全球数百万人。它在加拿大也成为一个流行病问题，根据加拿大统计局的数据，在2009-2010年，每50人中就有一人头部受伤。最近的研究表明，即使没有确诊脑震荡的轻微头部撞击（即次震荡性mTBI）也可能导致大脑功能或结构的可测量变化。更好地了解损伤机制对于改善诊断和预防这种普遍情况至关重要。本研究的长期目标是了解mTBI的生物力学机制。在这个为期5年的项目中，我们将专门研究轻度头部负荷的生物力学剂量与实时神经生理反应的关系。换句话说，我们将研究大脑在不同类型和严重程度的机械负荷下的实时变化。将建立一个可重复和通用的实验室头部载荷模型，以收集来自人类志愿者的轻度多向直接和鞭抽诱导的头部载荷数据。生物力学载荷参数将与脑电图测量的脑神经生理变化相关联。此外，将使用有限元脑模型模拟局部脑变形，并将其与区域神经生理变化进行比较。与传统研究相比，该研究项目将产生新的工程工具，用于研究轻度人类头部负荷下的实时大脑干扰，而传统研究是在机械输入后至少几个小时测量大脑反应。我们的发现将有助于对头部机械负荷如何导致大脑神经生理变化的基本理解。

Mild traumatic brain injury (mTBI), commonly known as concussions, affects millions annually worldwide. It is also becoming an epidemic problem in Canada, with one in fifty suffering a head injury in 2009-2010 according to Statistics Canada. Recent studies have shown that even milder head impacts without diagnosed concussions (i.e. subconcussive mTBI) could lead to measurable changes in brain function or structure. Having a better understanding of the injury mechanism is critical for improved diagnosis and prevention of this prevalent condition. The long-term objective of this research is to understand the biomechanical mechanism of mTBI. In this 5-year program, we will specifically investigate the biomechanical dose and real-time neurophysiological response relationship in mild head loading. In other words, we will study what real-time brain changes result from different types and severity of mechanical loading on the head. A repeatable and versatile laboratory head loading model will be built to gather mild multidirectional direct and whiplash-induced head loading data from human volunteers. The biomechanical loading parameters will be correlated with resulting brain neurophysiological changes measured by electroencephalogram. In addition, a finite element brain model will be used to simulate local brain deformations, which will be compared with regional neurophysiological changes. This research program will yield novel engineering tools to investigate real-time brain disturbances in mild human head loading, compared to traditional studies where the brain response is measured at least a few hours after the mechanical input. Our findings will contribute to fundamental understanding of how mechanical loading on the head leads to neurophysiological changes in the brain.