Characterizing the physiological response of the human brain to transcranial photobiomodulation

本研究旨在提高我们对经颅光生物调节（tPBM）的认识。tPBM包括在头部照射低电平激光或发光二极管。虽然对tPBM的生物学益处的研究可以追溯到20世纪60年代，但由于其工作效果如何以及如何调整参数以优化光穿透皮质的不确定性，临床转化一直受到限制。在这个建议中，我们使用先进的磁共振成像和脑电图来记录大脑对不同程度的刺激的反应。我们将测量脑血流量和代谢率有无tPBM。该结果将有助于建立tPBM的临床应用，也有助于优化tPBM在个性化医疗中的设计和使用。

This research is focused on improving our understanding of transcranial photobiomodulation (tPBM). tPBM involves shining a low-level laser or light-emitting diode on the head. While studies on the biological benefits of tPBM date back to the 1960's, clinical translation has been limited by uncertainties regarding how well it works and how to tune the parameters to optimize the light penetration to the cortex. In this proposal, we use advanced magnetic resonance imaging and electroencephalography to record the brain's response to varying levels of stimulation. We will measure the brain's blood flow and metabolic rates with and without tPBM. The outcome will help establish the clinical utility of tPBM and also help to optimize the design and use of tPBM for personalized medicine.