Development of a triple haemodynamic monitoring system for mammalian physiology studies

在这个提案中，我们将开发和测试一种新的设备，可以在不需要麻醉的情况下测量动物的心脏压力、心率和血流量。这种装置将被植入动物的腹部或背部，并有通过手术植入心脏的导线。为了开发这种设备，一组工程师将与UBC医学院的研究人员合作。这些设备将首先在实验室环境中进行测试，以优化数据收集协议、电源和电子设备，并确保设备可以远程充电。然后将设备通过手术植入动物体内，每天24小时对心脏压力、血流量和心率进行逐次采样，持续12周。我们还计划开发一种可以与遥测系统结合使用的新设备，使我们能够在不需要额外手术的情况下评估心脏收缩的强度。这些设备的开发和测试，以及我们将从同一动物体内获得的数据，将为生命科学领域提供重大进步，因为目前的方法无法长期跟踪所有这些指标，也无法评估心脏收缩的强度。这些设备有望在生命科学、医学和工业领域得到应用。

In this proposal we will develop and test a new device to measure heart pressure, heart rate and blood flow from animals without the need for anesthesia. This device will be implanted into the abdomen or on the back of the animal and have leads that are surgically implanted into the heart. To develop this device a team of engineers will work with researchers from the UBC Faculty of Medicine. The devices will first be tested in a laboratory setting to optimize data collection protocols, power supply, and electronics as well as to ensure the devices can be remotely charged. Devices will then be surgically implanted into the animal and heart pressure, blood flow, and rate will be sampled beat-by-beat for 24hrs per day for up to 12 weeks. We also plan to develop a new device that can be used in conjunction with the telemetry system to enable us to assess the strength of the heart's contraction without the need for additional surgery. The development and testing of these devices, as well as the data we will obtain from within the same animals over time, will provide a significant advancement to the life science field as current approaches are not able to track all of these indices over time or assess the strength of the hearts contraction over time. The devices are expected to have applications across the life sciences, medicine, and industry.