Role of brain dimensionality in altered states of consciousness.

我们正在进入一个不同科学学科之间史无前例地相互作用的时代，以揭开大脑的奥秘，如意识，这需要许多神经元的集体行为组织在一个高度复杂的交互架构中。长程动力学对于描述大脑皮层区域如何相互作用和提取大脑维度是必不可少的。这涉及到在三维物理空间之外设想新的度量空间，并在理解空间维度如何塑造信息流方面发挥基础作用。大脑动力学的数值模拟和建模正在达到新的现实主义水平，意识理论也变得更加复杂。我的发现计划的长期目标是通过开发更现实的模型来研究清醒和不同意识状态下的自发和刺激大脑活动，以保持我在脑动力学研究中的领先地位。我未来五年的短期目标是：1)开发一个更现实的广义伊辛模型(GIM)，根据清醒和睡眠等意识变化状态下的结构连通性和新陈代谢或脑成像活动来预测自发的大脑活动。2)在清醒状态和意识改变状态下使用自然主义听觉输入来表征刺激活动。我将修改开发的GIM，通过添加外部磁场和音频片段提取的轮廓来预测自发活动，以模拟刺激的效果。3)确定有无外加磁场的GIM在清醒和意识改变状态下的临界行为。我将计算每个意识水平的系统维度及其所研究的角色，以了解清醒和睡眠中的信息流。最后，我将计算在有和没有外磁场的情况下发展的GIM的综合信息和因果密度，以表征不同水平的意识。因果相互作用对系统维度的依赖性将被研究。将开发新的策略来研究意识的神经关联在大脑进化中的作用。我已经开展了许多国际合作，并期待积极参与神经科学界，为建立大脑的长期动态模型和理解支持意识的机制贡献新的见解。

We are entering an era of unprecedented interaction between different scientific disciplines to unravel the mysteries of the brain such as consciousness, which requires the collective behavior of many neurons organized in a highly sophisticated interactive architecture. Long -range dynamics are essential to describe how cortical areas interact and to extract brain dimensionality. This involves envisioning new metric spaces beyond the 3--dimensional physical space, and plays a fundamental role in understanding how space dimensionality shapes information flow. Numerical simulations and modeling of brain dynamics are reaching new levels of realism, and theories of consciousness are becoming more sophisticated. My long -term Discovery program objective is to maintain my leading role in brain dynamics research through the development of more realistic models of spontaneous and stimulated brain activity during wakefulness and in different states of altered consciousness such as sleep. My short- term objectives for the next five years are: 1) to develop a more realistic Generalized Ising Model (GIM) to predict spontaneous brain activity from structural connectivity and metabolic or encephalography activity in wakefulness and altered states of consciousness such as sleep. 2) To characterize stimulated activity using engaging naturalistic auditory input in wakefulness and in altered states of consciousness. I will modify the developed GIM to predict spontaneous activity by adding an external magnetic field with a profile extracted by the audio clip to model the effect of stimulation. 3) To determine the critical behavior of the GIM with and without an external magnetic field in wakefulness and altered states of consciousness. I will calculate dimensionality of the system for each level of consciousness and its role investigated to understand information flow in awake and under sleep. Finally I will calculate integrated information and causal density for the developed GIMs with and without an external magnetic field to characterize the different levels of consciousness. The dependence of causal interaction on the system's dimensionality will be investigated. New strategies will be developed to investigate the role of neural correlates of consciousness in the evolution of the brain. I have many international collaborations in place and expect to participate actively in the neuroscience community to contribute new insights into modeling the long -range dynamics of the brain and to the understanding of the mechanisms that support consciousness.