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Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.

Germline DNMT3A loss-of-function alters PRC2-dependent H3K27me3 deposition and leads to neuronal impairments.
种系 DNMT3A 功能丧失会改变 PRC2 依赖性 H3K27me3 沉积并导致神经元损伤。
批准号：
493576
负责人：
McGraw Serge
金额：
$7.29万
依托单位：
Centre hospitalier universitaire Sainte-Justine (Montral, Qubec)
依托单位国家：
加拿大
项目类别：
Operating Grants
财政年份：
2023
资助国家：
加拿大
项目状态：
已结题
起止时间：
2023-09-01 至 2024-09-01
来源：
https://webapps.cihr-irsc.gc.ca/decisions/p/project_details.html?applId=493576&lang=en
关键词：
Bioinformatics Brain Development Dna Methyltransferase 3a (Dnmt3a) Epigenetics Induced Pluripotent Stem Cells (Ipsc) Mouse Model Multiomic Approaches Polycomb Repressive Complex 2 (Prc2)

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