二肽基有序分子组装体可控相变及其机理研究

短肽具有结构丰富、易于化学修饰和优异的生物相容性与生物可降解性等特征，已成为通过自下而上的方式构筑纳米生物材料非常有潜质的基元。本项目拟利用分子自组装技术，紧密围绕苯丙氨酸二肽基分子聚集体的可控相变与功能化开展研究工作，重点探索它们在特定物理条件下或外界化学环境介导的相变（包括溶胶-凝胶-晶体、晶体-晶体和聚集体-聚集体等）规律，详细阐明系列相态下分子排布的独特形式，考察组装体相变动力学和热力学机制，建立多层次动态组装调控新策略，构建精准有序、性能优异的二肽基材料新体系，初步探索它们在功能光电子器件、智能生物反应器以及药物程序性释放等方面的应用。

Short peptides have become promising building blocks to construct nanoscaled biomaterials because of their favorable features including diverse structures, easy chemical modification, excellent biocompatibility and biodegradability. By using molecular assembly techniques, this project will focus on controlled phase transitions and functionalization of diphenylalanine-based order aggregates. We will explore the principles and mechanisms of phase transitions (including sol-gel-crystal, crystal-crystal, aggregate-aggregate) mediated by special physical factors and chemical environments. Also, we will elucidate molecular arrangements in every phase and investigate the relevant kinetics and thermodynamics. In addition, new strategies will be developed to achieve dynamic assembly of diphenylalanine-based hierarchical aggregates with precisely-ordered structure and excellent performance. Finally, they will be used in optoelectronic devices, smart bioreactors and programmable drug delivery.