Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study.
Alcohol consumption and all-cause and cause-specific mortality among US adults: prospective cohort study.
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DOI：
10.1186/s12916-023-02907-6
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发表时间：
2023-06-07
期刊：
影响因子：
9.3
通讯作者：
Wang, Xia
中科院分区：
文献类型：
--
作者：
Tian, Yalan;Liu, Jiahui;Zhao, Yue;Jiang, Nana;Liu, Xiao;Zhao, Gang;Wang, Xia
关键词：
先前的研究表明，关于轻度至中度饮酒与死因特异性死亡率之间的关系，研究结果不一致。因此，本研究旨在研究美国人群中酒精消费与全因和特定原因死亡率的前瞻性关联。这是一项基于人群的队列研究，研究对象为国家健康访谈调查（1997年至2014年）中18岁或以上的成年人，与截至2019年12月31日的国家死亡指数记录相关。自我报告的饮酒量被分为七组（终身戒酒者;以前不经常或经常饮酒者;和目前不经常，轻度，中度或重度饮酒者）。主要结局是全因和原因特异性死亡率。在平均12.65年的随访期间，在918，529名参与者中，（平均年龄46.1岁; 141，512名成年人死于各种原因，43，979人死于心血管疾病，33，222人死于癌症，8，246人死于慢性下呼吸道疾病，5，572人死于事故（无意伤害），4776例来自阿尔茨海默病，4845例来自糖尿病，2815例来自流感和肺炎，2692例来自肾炎、肾病综合征或肾病。与终生戒酒者相比，目前不常饮酒、轻度或中度饮酒者的各种原因死亡风险较低[不常饮酒风险比：0.87; 95%置信区间：0.84 - 0.90;轻度：0.77; 0.75 - 0.79;中度：0.82; 0.80至0.85]、CVD、慢性下呼吸道疾病、阿尔茨海默病、以及流感和肺炎。此外，轻度或中度饮酒者与糖尿病和肾炎、肾病综合征或肾病的死亡风险较低有关。相比之下，大量饮酒者因各种原因、癌症和意外事故（意外伤害）而死亡的风险明显更高。此外，酗酒≥ 1天/周与全因死亡（1.15; 1.09至1.22）、癌症（1.22; 1.10至1.35）和意外事故（意外伤害）（1.39; 1.11至1.74）的风险较高相关。不经常、轻度和中度饮酒与所有原因、心血管疾病、慢性下呼吸道疾病、阿尔茨海默病、流感和肺炎的死亡率呈负相关。轻度或中度饮酒也可能对糖尿病和肾炎、肾病综合征或肾病的死亡率有有益的影响。然而，重度或狂欢有更高的全因、癌症和意外（意外伤害）死亡率的风险。在线版本包含补充材料，可通过10.1186/s12916-023-02907-6获得。
Previous studies have shown inconsistent findings regarding the association of light to moderate alcohol consumption with cause-specific mortality. Therefore, this study sought to examine the prospective association of alcohol consumption with all-cause and cause-specific mortality in the US population. This was a population-based cohort study of adults aged 18 years or older in the National Health Interview Survey (1997 to 2014) with linkage to the National Death Index records through December 31, 2019. Self-reported alcohol consumption was categorized into seven groups (lifetime abstainers; former infrequent or regular drinkers; and current infrequent, light, moderate, or heavy drinkers). The main outcome was all-cause and cause-specific mortality. During an average follow-up of 12.65 years, among the 918,529 participants (mean age 46.1 years; 48.0% male), 141,512 adults died from all causes, 43,979 from cardiovascular disease (CVD), 33,222 from cancer, 8246 from chronic lower respiratory tract diseases, 5572 from accidents (unintentional injuries), 4776 from Alzheimer’s disease, 4845 from diabetes mellitus, 2815 from influenza and pneumonia, and 2692 from nephritis, nephrotic syndrome, or nephrosis. Compared with lifetime abstainers, current infrequent, light, or moderate drinkers were at a lower risk of mortality from all causes [infrequent—hazard ratio: 0.87; 95% confidence interval: 0.84 to 0.90; light: 0.77; 0.75 to 0.79; moderate 0.82; 0.80 to 0.85], CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Also, light or moderate drinkers were associated with lower risk of mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. In contrast, heavy drinkers had a significantly higher risk of mortality from all causes, cancer, and accidents (unintentional injuries). Furthermore, binge drinking ≥ 1 day/week was associated with a higher risk of mortality from all causes (1.15; 1.09 to 1.22), cancer (1.22; 1.10 to 1.35), and accidents (unintentional injuries) (1.39; 1.11 to 1.74). Infrequent, light, and moderate alcohol consumption were inversely associated with mortality from all causes, CVD, chronic lower respiratory tract diseases, Alzheimer’s disease, and influenza and pneumonia. Light or moderate alcohol consumption might also have a beneficial effect on mortality from diabetes mellitus and nephritis, nephrotic syndrome, or nephrosis. However, heavy or binge had a higher risk of all-cause, cancer, and accidents (unintentional injuries) mortality. The online version contains supplementary material available at 10.1186/s12916-023-02907-6.
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影响因子：
2.9
作者：
Ferrari, Pietro;Licaj, Idlir;Romieu, Isabelle
通讯作者：
Romieu, Isabelle
影响因子：
13.6
作者：
Bobak M;Malyutina S;Horvat P;Pajak A;Tamosiunas A;Kubinova R;Simonova G;Topor-Madry R;Peasey A;Pikhart H;Marmot MG
通讯作者：
Marmot MG
影响因子：
5.9
作者：
Barberia-Latasa, Maria;Gea, Alfredo;Martinez-Gonzalez, Miguel A.
通讯作者：
Martinez-Gonzalez, Miguel A.
影响因子：
4.6
作者：
Choi YJ;Myung SK;Lee JH
通讯作者：
Lee JH
DOI：
10.15288/jsa.1991.52.156
发表时间：
1991-03-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
GOODMAN, RA;ISTRE, GR;KELAGHAN, J
通讯作者：
KELAGHAN, J