Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies.
Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies.
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DOI：
10.4143/crt.2017.094
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发表时间：
2018-04
影响因子：
4.6
通讯作者：
Lee JH
中科院分区：
文献类型：
--
作者：
Choi YJ;Myung SK;Lee JH
这项研究的目的是通过使用队列研究的荟萃分析来确定轻度饮酒是否会增加癌症的风险，因为新修订的2015年欧洲癌症防治法典第四版关于酒精和癌症的内容是基于先前荟萃分析的解释和引用中的关键缺陷。2016年4月检索了PubMed和EMBASE。两位作者独立审查并选择了关于非常少量（≤ 0.5杯/天）、少量（≤ 1杯/天）或中度饮酒（1-2杯/天）与癌症发病率和死亡率风险之间关系的队列研究。通过随机效应荟萃分析计算合并相对风险及其95%置信区间。主要结果指标为癌症发病率和死亡率。最终分析纳入了来自135篇文章的60项队列研究。除女性乳腺癌和男性结直肠癌外，极少量饮酒或少量饮酒与大多数癌症的发病率无关。相反，轻度饮酒与女性和男性肺癌发病率的显著下降相关，女性和男性甲状腺癌的发病率也略有下降。适量饮酒显著增加男性结直肠癌和女性乳腺癌的发病率，而降低女性和男性血液系统恶性肿瘤的发病率。我们发现，非常少量或少量饮酒与大多数常见癌症的风险无关，除了女性乳腺癌和男性结直肠癌的发病率略有增加。
The purpose of this study was to determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer fourth edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses. PubMed and EMBASE were searched in April, 2016. Two authors independently reviewed and selected cohort studies on the association between very light (≤ 0.5 drink/day), light (≤ 1 drink/day), or moderate drinking (1-2 drinks/day) and the risk of cancer incidence and mortality. A pooled relative riskwith its 95% confidence intervalwas calculated by a random-effects meta-analysis. Main outcome measures were cancer incidence and mortality. A total of 60 cohort studies from 135 articles were included in the final analysis. Very light drinking or light drinking was not associated with the incidence of most cancers except for female breast cancer in women and male colorectal cancer. Conversely, light drinking was associated with a decreased incidence of both female and male lung cancer significantly and both female and male thyroid cancer marginally significantly. Moderate drinking significantly increased the incidence of male colorectal cancer and female breast cancer,whereas it decreased the incidence of both female and male hematologic malignancy. We found that very light or light alcohol drinking was not associated with the risk of most of the common cancers except for the mild increase in the incidence of breast cancer in women and colorectal cancer in men.
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影响因子：
39.3
作者：
Imhof, A;Woodward, M;Koenig, W
通讯作者：
Koenig, W
影响因子：
2.3
作者：
Feigelson, HS;Calle, EE;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
13.6
作者：
Chen, K;Jiang, QT;Zheng, S
通讯作者：
Zheng, S
影响因子：
5
作者：
Falk, Roni T.;Maas, Paige;Ziegler, Regina G.
通讯作者：
Ziegler, Regina G.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N