Localized activity alternations in periventricular nodular heterotopia-related epilepsy.
Localized activity alternations in periventricular nodular heterotopia-related epilepsy.
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脑室周围结节性异位相关性癫痫的局部活动交替
DOI：
10.1111/cns.14104
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发表时间：
2023-05
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
脑室周围结节性异位是一种常见的异位症，常以癫痫为特征。以前的研究已经确定了与这种疾病相关的结构和功能连接的改变，但其局部功能神经基础受到的关注较少。本研究的目的是将联合收割机单变量分析和高斯过程分类器（GPC）相结合，以评估PNH相关癫痫的局部活动并进一步探讨其神经病理机制。我们使用3.0 T扫描仪采集38例PNH相关癫痫患者和38例健康对照（HC）的静息状态数据并测量局部区域均匀性（ReHo）改变。我们首先使用传统的单变量分析比较PNH组和HC组，评估ReHo改变。接下来，我们应用GPC来探索ReHo是否可以用于在个体水平上区分PNH患者和健康患者。与HC相比，PNH相关癫痫患者在延伸至壳核的左丘脑以及延伸至眶额皮质（OFC）的膝下前扣带回皮质（sgACC）中表现出较低的ReHo [p < 0.05，家族误差校正]。这两个区域也与癫痫持续时间相关。此外，ReHo GPC分类产生了76.32%的准确性（敏感性= 71.05%，特异性= 81.58%），在排列检验后p < 0.001。使用静息状态方法，我们确定了延伸到壳核的左丘脑和延伸到OFC的sgACC的局部活性改变，为PNH提供了病理生理学证据。这些局部连接模式可以提供区分PNH患者与HC的手段。PNH相关癫痫患者在延伸至壳核的左丘脑和延伸至眶额皮质（OFC）的膝下前扣带回皮质（sgACC）中表现出较低的区域均匀性（ReHo）[p < 0.05，家族误差（FWE）校正]。癫痫发作持续时间与ReHo值呈负相关。此外，关于ReHo的GPC分类在排列检验后产生了76.32%的准确性（灵敏度= 71.05%，特异性= 81.58%），p < 0.001。
Periventricular nodular heterotopia (PNH) is a common type of heterotopia usually characterized by epilepsy. Previous studies have identified alterations in structural and functional connectivity related to this disorder, but its local functional neural basis has received less attention. The purpose of this study was to combine univariate analysis and a Gaussian process classifier (GPC) to assess local activity and further explore neuropathological mechanisms in PNH‐related epilepsy. We used a 3.0‐T scanner to acquire resting‐state data and measure local regional homogeneity (ReHo) alterations in 38 patients with PNH‐related epilepsy and 38 healthy controls (HCs). We first assessed ReHo alterations by comparing the PNH group to the HC group using traditional univariate analysis. Next, we applied a GPC to explore whether ReHo could be used to differentiate PNH patients from healthy patients at an individual level. Compared to HCs, PNH‐related epilepsy patients exhibited lower ReHo in the left insula extending to the putamen as well as in the subgenual anterior cingulate cortex (sgACC) extending to the orbitofrontal cortex (OFC) [p < 0.05, family‐wise error corrected]. Both of these regions were also correlated with epilepsy duration. Furthermore, the ReHo GPC classification yielded a 76.32% accuracy (sensitivity = 71.05% and specificity = 81.58%) with p < 0.001 after permutation testing. Using the resting‐state approach, we identified localized activity alterations in the left insula extending to the putamen and the sgACC extending to the OFC, providing pathophysiological evidence of PNH. These local connectivity patterns may provide a means to differentiate PNH patients from HCs. PNH‐related epilepsy patients exhibited lower regional homogeneity (ReHo) in the left insula extending to putamen and also the subgenual anterior cingulate cortex (sgACC) extending to orbitofrontal cortex (OFC) [p < 0.05, family‐wise error (FWE) correction]. The epilepsy duration was negatively and independently associated with the ReHo value. Furthermore, the GPC classification regarding ReHo yielded an accuracy of 76.32% (sensitivity = 71.05% and specificity = 81.58%) with p < 0.001 after permutation testing.
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影响因子：
5.7
作者：
Pereira F;Mitchell T;Botvinick M
通讯作者：
Botvinick M
影响因子：
3.7
作者：
Song XW;Dong ZY;Long XY;Li SF;Zuo XN;Zhu CZ;He Y;Yan CG;Zang YF
通讯作者：
Zang YF
DOI：
10.1016/j.yebeh.2013.08.028
发表时间：
2013-11
期刊：
Epilepsy & behavior : E&B
影响因子：
--
作者：
Christodoulou JA;Barnard ME;Del Tufo SN;Katzir T;Whitfield-Gabrieli S;Gabrieli JD;Chang BS
通讯作者：
Chang BS
影响因子：
4.1
作者：
Nolan RL;Brandmeir N;Tucker ES;Magruder JL;Lee MR;Chen G;Lewis JW
通讯作者：
Lewis JW
影响因子：
5.7
作者：
Deng, Shengwen;Franklin, Crystal G.;O'Boyle, Michael;Zhang, Wei;Heyl, Betty L.;Jerabek, Paul A.;Lu, Hanzhang;Fox, Peter T.
通讯作者：
Fox, Peter T.