Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease.
Locus coeruleus neuron density and parkinsonism in older adults without Parkinson's disease.
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DOI：
10.1002/mds.25142
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发表时间：
2012-11
影响因子：
8.6
通讯作者：
Bennett, David A.
中科院分区：
文献类型：
--
作者：
Buchman, Aron S.;Nag, Sukriti;Shulman, Joshua M.;Lim, Andrew S. P.;VanderHorst, Veronique G. J. M.;Leurgans, Sue E.;Schneider, Julie A.;Bennett, David A.
先前的工作表明，黑质神经元密度与帕金森氏症的严重程度有关，在没有帕金森氏病（PD）临床诊断的老年人中接近死亡。我们测试的假设，在其他脑干胺能核的神经元密度也与帕金森综合征的严重程度。我们研究了125名参加记忆与衰老项目（一项临床病理调查）的无PD的已故老年人的脑尸检。帕金森综合征采用改良版的统一帕金森病评定量表（UNITED PARKINSONS RATING SCALE）进行评估。我们测量了黑质、腹侧被盖区、蓝斑和中缝背核的神经元密度，以及路易体阿尔茨海默病和脑血管病变的死后指数。平均死亡年龄为88.0岁，全身帕金森综合征为14.8岁（SD=9.50）。在一系列控制人口统计学和黑质神经元密度的回归模型中，蓝斑神经元密度（估计值，-0.261，S.E.，0.117，p=0.028），但在腹侧被盖区或中缝背侧与接近死亡的全面帕金森症的严重程度无关。这些发现在控制死后间隔、全脑重量和其他常见神经病理学（包括阿尔茨海默病和路易体病理学和脑血管病理学）的模型中没有变化。在没有临床诊断为PD的老年人中，蓝斑核中的神经元密度与帕金森综合征的严重程度相关，并可能导致晚年运动障碍。
Prior work has showed that nigral neuron density is related to the severity of parkinsonism proximate to death in older persons without a clinical diagnosis of Parkinson’s disease (PD). We tested the hypothesis that neuron density in other brainstem aminergic nuclei is also related to the severity of parkinsonism. We studied brain autopsies from 125 deceased older adults without PD enrolled in the Memory and Aging Project, a clinical-pathologic investigation. Parkinsonism was assessed with a modified version of the Unified Parkinson’s Disease Rating Scale (UPDRS). We measured neuron density in the substantia nigra, ventral tegmental area, locus coeruleus and dorsal raphe; and postmortem indices of Lewy body Alzheimer’s disease and cerebrovascular pathologies. Mean age at death was 88.0 and global parkinsonism was 14.8 (SD=9.50). In a series of regression models which controlled for demographics and neuron density in the substantia nigra, neuron density in the locus coeruleus (Estimate, −0.261, S.E., 0.117, p=0.028) but not in the ventral tegmental area or dorsal raphe was associated with the severity of global parkinsonism proximate to death. These findings were unchanged in models which controlled for post-mortem interval, whole brain weight and other common neuropathologies including Alzheimer’s disease and Lewy body pathology and cerebrovascular vascular pathologies. In older adults without a clinical diagnosis of PD, neuron density in locus coeruleus nuclei is associated with the severity of parkinsonism and may contribute to late-life motor impairments.
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DOI：
10.1002/cne.23024
发表时间：
2012-06-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Bruinstroop E;Cano G;Vanderhorst VG;Cavalcante JC;Wirth J;Sena-Esteves M;Saper CB
通讯作者：
Saper CB
影响因子：
--
作者：
Zarow, C;Lyness, SA;Chui, HC
通讯作者：
Chui, HC
影响因子：
8.6
作者：
Louis, Elan D.;Tang, Ming X.;Schupf, Nicole
通讯作者：
Schupf, Nicole
影响因子：
11.2
作者：
Ross, GW;Petrovitch, H;White, LR
通讯作者：
White, LR
影响因子：
--
作者：
DelleDonne, Anthony;Klos, Kevin J.;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.