Vascular considerations in glaucoma patients of African and European descent.
Vascular considerations in glaucoma patients of African and European descent.
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DOI：
10.1111/aos.12354
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发表时间：
2014-08
影响因子：
3.4
通讯作者：
Abrams-Tobe L
中科院分区：
文献类型：
--
作者：
Huck A;Harris A;Siesky B;Kim N;Muchnik M;Kanakamedala P;Amireskandari A;Abrams-Tobe L
青光眼是非洲裔（AD）个体失明的主要原因。虽然开角型青光眼（OAG）与欧洲血统的人（艾德）相比不成比例地影响AD个体;但是这种差异背后的生理机制在很大程度上是未知的。AD患者的疾病进展更快，严重程度更高，这进一步引起了人们对AD和艾德青光眼患者之间疾病病理生理学差异的关注。AD和艾德患者的眼部结构存在差异，包括视盘面积、杯盘比和角膜厚度的增加，AD患者还易患高血压、心血管疾病、中风和糖尿病等全身性血管疾病。异常的眼部血流被认为是青光眼的一个危险因素，初步研究开始确定AD和艾德OAG患者之间的局部眼部血管差异。鉴于已知的全身血管缺陷和青光眼与眼血流之间的关系，探索这些概念的青光眼危险因素可能会有显着的影响，阐明背后的AD人群的疾病差异的机制。
Glaucoma is the leading cause of blindness in individuals of African descent (AD). While open angle glaucoma (OAG) disproportionately affects individuals of AD compared to persons of European descent (ED); the physiological mechanisms behind this disparity are largely unknown. The more rapid progression and greater severity of the disease in persons of AD further raises the concern for identifying these underlying differences in disease pathophysiology between AD and ED glaucoma patients. Ocular structural differences between AD and ED patients, including larger optic disc area, cup:disc ratio and thinner corneas have been found. AD individuals are also disproportionately affected by systemic vascular diseases including: hypertension, cardiovascular disease, stroke and diabetes mellitus. Abnormal ocular blood flow has been implicated as a risk factor for glaucoma, and pilot research is beginning to identify localized ocular vascular differences between AD and ED OAG patients. Given the known systemic vascular deficits and the relationship between glaucoma and ocular blood flow, exploring these concepts in terms of glaucoma risk factors may have a significant impact in elucidating the mechanisms behind the disease disparity in the AD population.
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DOI：
10.3129/i08-051
发表时间：
2008-06-01
影响因子：
4.2
作者：
Harris, Alon;Kagemann, Larry;Siesky, Brent
通讯作者：
Siesky, Brent
影响因子：
120.7
作者：
FARQUHAR, JW;FORTMANN, SP;WOOD, PD
通讯作者：
WOOD, PD
影响因子：
4.1
作者：
Foster, PJ;Buhrmann, R;Johnson, GJ
通讯作者：
Johnson, GJ
影响因子：
--
作者：
Friedman, David S.;Jampel, Henry D.;West, Sheila K.
通讯作者：
West, Sheila K.
影响因子：
4.1
作者：
Chung, HS;Harris, A;Martin, B
通讯作者：
Martin, B